PPT-Liver and Cardiac Enzymes and Drug Interference

By Zohreh Rahimi Professor of Clinical Biochemistry 1 TESTS OF LIVER INJURY PLASMA ENZYME LEVELS As metabolically complex cells hepatocytes contain high levels of a number of enzymes With liver injury these enzymes may leak into plasma and can . By Aidan Cross and Tom Grant. How many phases of drug . metabolism are there? (1 mark). 3 Phases. . What . is phase 1 of drug metabolism? (2). Provide a functional group (e.g. OH or NH. 2. ) to:. increase polarity of the drug. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. By Michael W. Bowers. CK-MB. 3hr, peak 12-24hr lasts 1-3 days. Troponin. 3-12 hrs, peak 12-24hr, lasts 8-21 days Trop-T and 7-14 Trop-I . What is Creatine Kinase?. What is Creatine Kinase?. Creatine kinase is an enzyme . Department of Pharmaceutics. . . Drug metabolism or Biotransformation is the major mechanism for elimination of drug from the body.. . It is the process by which the drug is chemically modified . 1. What are enzymes?. Each enzyme has only one specific reaction it can perform. . 2. How many different reactions can a single enzyme perform?. Yes, the same enzyme molecule can be used over and over. protein. !. Enzymes are . Biological . catalysts . that . increase. . the rate of metabolic reactions.. Since enzymes speed up chemical reaction rates, what are they called?. Catalyst- . A substance . disease. Penny North-Lewis. Paediatric Liver Pharmacist. Leeds . Children’s Hospital. September 2019. Where is the liver?. What does the liver do?. Synthesis. . (e.g. albumin & clotting . factors, cholesterol). By. Zohreh. . Rahimi. Professor of Clinical Biochemistry. 1. TESTS OF LIVER INJURY. PLASMA ENZYME LEVELS. As metabolically complex cells, hepatocytes contain high levels of a number . of . enzymes. With liver injury, these enzymes may leak into plasma and can . Luana Pesco Koplowitz, MD, PhD, FCP, FFPM. President and Chief Medical & Scientific Officer. DUCK FLATS Pharma. Elbridge, New York, . and Stockton, New Jersey USA. Adjunct Assistant Professor of Medicine. Restriction enzymes. Polymerase enzyme. Strand-displacing polymerases. Helicase enzymes. Discovery and Obtainability:. Most enzymes are proteins discovered in cells.. But . DNAzymes. were . descovered. Here are some cardiac problem signs including chest discomfort, nausea, throat or jaw pain and more which you should never ignore. Shari L. Targum, MD, MPH, FACC. Medical Officer. U.S. Food and Drug Administration. Detecting cardiac safety signals. Common, drug-related. : can detect in placebo-controlled, clinical trials, compare to background rate. . . failure of the heart to pump blood adequately. Cardiac failure is manifested by two ways---. 1) . C.O.. 2) . C.O.. . . . that . catalyze. (. i.e.. , . increase or decrease the rates. of) . chemical reactions. .. . In enzymatic reactions, the . molecules. at the beginning of the process are called . substrates. , and they are converted into different molecules, called the .