PPT-Liver and Cardiac Enzymes and Drug Interference

By Zohreh Rahimi Professor of Clinical Biochemistry 1 TESTS OF LIVER INJURY PLASMA ENZYME LEVELS As metabolically complex cells hepatocytes contain high levels of a number of enzymes With liver injury these enzymes may leak into plasma and can . By . Jayly. . Sawangsaen. and . DangMinh. Nguyen. Functions of the liver. Organ in body, filters blood, detoxifies and metabolizes.. Secretes bile and makes proteins.. Food in the liver. Food does not directly go into liver. By Aidan Cross and Tom Grant. How many phases of drug . metabolism are there? (1 mark). 3 Phases. . What . is phase 1 of drug metabolism? (2). Provide a functional group (e.g. OH or NH. 2. ) to:. increase polarity of the drug. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. (Diagnostic & Therapeutic ) . importance of . Enzymes and isoenzymes. Objectives. List the clinically important enzymes and . isoenzymes. .. State which of the enzymes and . isoenzymes. are found in which tissues. METABOLISM OR BIOTRANSFORMATION . The conversion from one chemical form of a substance to another. . The term metabolism is commonly used probably because products of drug transformation are called . Phase I and II reactions . Xenobiotics . Foreign chemical substance . Can be absorbed across lungs, skin or ingested . Drugs are considered xenobiotics . Excreted in bile, urine, sweat, breath . Pharmacologically Active Compounds. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. Mike Clark, M.D.. Isozymes. (also known as . isoenzymes. ) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes usually display different kinetic parameters (e.g. different . By Michael W. Bowers. CK-MB. 3hr, peak 12-24hr lasts 1-3 days. Troponin. 3-12 hrs, peak 12-24hr, lasts 8-21 days Trop-T and 7-14 Trop-I . What is Creatine Kinase?. What is Creatine Kinase?. Creatine kinase is an enzyme . Department of Pharmaceutics. . . Drug metabolism or Biotransformation is the major mechanism for elimination of drug from the body.. . It is the process by which the drug is chemically modified . disease. Penny North-Lewis. Paediatric Liver Pharmacist. Leeds . Children’s Hospital. September 2019. Where is the liver?. What does the liver do?. Synthesis. . (e.g. albumin & clotting . factors, cholesterol). Luana Pesco Koplowitz, MD, PhD, FCP, FFPM. President and Chief Medical & Scientific Officer. DUCK FLATS Pharma. Elbridge, New York, . and Stockton, New Jersey USA. Adjunct Assistant Professor of Medicine. By. Zohreh. . Rahimi. Professor of Clinical Biochemistry. 1. TESTS OF LIVER INJURY. PLASMA ENZYME LEVELS. As metabolically complex cells, hepatocytes contain high levels of a number . of . enzymes. With liver injury, these enzymes may leak into plasma and can . 90 Turk J Pharm Sc, Publshed by Galenos Publshng House. *Correspondence: eke@pharmacy.ankara.edu.tr, Phone:Receved:Accepted: Bu derlemede flavin-içeren monooksijenazların (F