PPT-Liver and Cardiac Enzymes and Drug Interference

By Zohreh Rahimi Professor of Clinical Biochemistry 1 TESTS OF LIVER INJURY PLASMA ENZYME LEVELS As metabolically complex cells hepatocytes contain high levels of a number of enzymes With liver injury these enzymes may leak into plasma and can . Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. METABOLISM OR BIOTRANSFORMATION . The conversion from one chemical form of a substance to another. . The term metabolism is commonly used probably because products of drug transformation are called . By Michael W. Bowers. CK-MB. 3hr, peak 12-24hr lasts 1-3 days. Troponin. 3-12 hrs, peak 12-24hr, lasts 8-21 days Trop-T and 7-14 Trop-I . What is Creatine Kinase?. What is Creatine Kinase?. Creatine kinase is an enzyme . IMPORTANCE. OF ENZYMES. Enzymes are biological catalysts that:. . I. ncrease. . reaction rates . by lowering the amount of energy needed for the reaction to occur. 100-1000x . faster. !!!. Activation Energy. protein. !. Enzymes are . Biological . catalysts . that . increase. . the rate of metabolic reactions.. Since enzymes speed up chemical reaction rates, what are they called?. Catalyst- . A substance . Part 1. . Chapter 3. Learning outcomes. You should be able to:. explain how enzymes work. describe and explain the factors that affect. enzyme activity. use V. max. and K. m. to compare the affinity of different enzymes for their substrates. disease. Penny North-Lewis. Paediatric Liver Pharmacist. Leeds . Children’s Hospital. September 2019. Where is the liver?. What does the liver do?. Synthesis. . (e.g. albumin & clotting . factors, cholesterol). 2017; 16 (3): 442-450 Abdominal ultra-tients were followed up for at least 6 months or until Patients with pre-exist- MELD score was calculated (creatinine mg/dL) + 3.8 x log (international normal- Enzymes. Back when we discussed proteins, we learned that one critical function of protein was to speed up chemical reactions.. Enzymes. are the proteins that increase the rate of chemical reactions. Here are some cardiac problem signs including chest discomfort, nausea, throat or jaw pain and more which you should never ignore. Shari L. Targum, MD, MPH, FACC. Medical Officer. U.S. Food and Drug Administration. Detecting cardiac safety signals. Common, drug-related. : can detect in placebo-controlled, clinical trials, compare to background rate. . . failure of the heart to pump blood adequately. Cardiac failure is manifested by two ways---. 1) . C.O.. 2) . C.O.. . . . Download PDF Fatty Liver Remedy™ eBook by Layla Jeffrey - a comprehensive guide designed to address and alleviate the symptoms of fatty liver disease through natural and lifestyle-based approaches. Download PDF The Fatty Liver Solution™ eBook by Duncan Capicchiano - A natural and effective approach to tackling fatty liver disease.