PPT-P&S Genomics Lecture 8a: GenASM

Joël Lindegger ETH Zürich Spring 2023 27 April 2023 Genome Sequencing Genome sequencing Enables us to determine the order of the DNA sequence in an organisms genome Plays a pivotal role . selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. Name one important thing that you learnt from this course that you feel will be important to your research career. Name one aspect you were hoping to learn that you did not. Pharm 201 Lecture 19, 2011. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. (. dsenol@andrew.cmu.edu. ). Gurpreet S. Kalsi. 2. , . Zulal. Bingol. 3. , Can Firtina. 4. , Lavanya Subramanian. 5. ,. Jeremie Kim. 1,4. , Rachata Ausavarungnirun. 6,1. , Mohammed Alser. 4. , . Juan Gomez-Luna. Overview and Capabilities: . . High Throughput Sequencing Facility (HTSG). Functional Genomics M. ammalian Genotyping Core (MGC). Corbin Jones. Faculty Director. Piotr . Meiczkowski . Technologies . What is Structural Genomics ?. Is the process of high-. throughtput. determination of 3-D structures of Biological macromolecules. What is the Goal of Structural Genomics ?. Provision of enough structural templates to facilitate homology modeling of most proteins.. 15, 2021. dsenol@andrew.cmu.edu. . Committee: . Prof. Onur Mutlu (CMU, ETH Zurich). Prof. Saugata Ghose (CMU, UIUC). Prof. James C. Hoe (CMU). Prof. Can Alkan (Bilkent University). “. User facility. providing high-throughput DNA sequencing & analysis in support of DOE missions in alternative . energy. , . carbon cycling . & . bioremediation. .”. Opened in 1999. ~240 UC Employees. Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& . Carl Pray. 1. Can advances in biology transform Asian agriculture? Challenges are large. Food production . Productivity growth . Crises – . Biological -Africa Swine Fever, corn stalk borer, fall armyworm, wheat rust. https://damlasenolcali.github.io. TECHCON’. 21. ⎼ September . 14, 2021. . . GenGraph: A Hardware Acceleration Framework . for Sequence-to-Graph Mapping. Genome Sequencing. Genome sequencing: . What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ian Green. Clinical Engagement and Education Business Manager. Strategy. Work undertaken by Genome One (part of the . Garvan. Institute). Work underway. Completion date . –. 17. th. , March 2017. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .