PPT-A New Model for Coalescent with Recombination

Zhi Ming Ma ECM2013 PolyU Email mazmamtaccn httpwwwamtaccnmembermazhimingindexhtml A New Method for Coalescent Processes with Recombination . Jelle Kaastra. with. . Ton . Raassen. , . Liyi. . Gu. , . Junjie. Mao, . Igone. . Urdampilleta. , . Missagh. . Mehdipour. SRON & Leiden University. Introduction. X-ray emitting plasmas everywhere:. Summary of assumptions so far. We have covered the role of chance (parent choice), demography (population size) and mutation, in shaping genetic diversity. . Neutral Wright-Fisher . models. Parents are always chosen at random. This means no new mutations affect reproductive success of parents, i.e. . In the complex model we allow for differing defect and band occupation densities and calculate the recombination as. Where: . A. τ. = 1 / defect capture time (1/. τ. ). . B. = radiative constant . CSE280. Vineet Bafna. Expectation, and deviance. Statements such as the ones below can be made only if we have an underlying model that suggests what we should expect. . Recombination rates vary dramatically across the genome. CSE280. Vineet Bafna. Expectation, and deviance. Statements such as the ones below can be made only if we have an underlying model that suggests what we should expect. . Recombination rates vary dramatically across the genome. Lecture . 26. th. Alexei Fedorov, 2014. Origin of Chess. http://www.expert-chess-strategies.com/who-invented-chess.html. http://www.ponderabout.com/archives/972/mind-boggling-exponential-growth.aspx. Genetics (SC1). Simon Myers . . Email: . myers@stats.ox.ac.uk. . Course webpage: . www.stats.ox.ac.uk/~myers/mathgen.html. Class problem sheets . are . posted . online (separate sheets for MSc and Part C). Alexei Fedorov. Recombination is an intrinsic property of nucleic acids and these molecules are susceptible to joining their ends. .. Evolution invented thousands of proteins that assist DNA recombination and became crucial for cell functioning. . Gene Tree Probability. under the . Multispecies Coalescent . and its Application in the Inference of Population Tree. Yufeng. . Wu. Dept. of Computer Science & Engineering. University of Connecticut, USA. Yufeng Wu. University of Connecticut. DIMACS Workshop on Algorithmics in Human Population-Genomics, 2009. 1. Coalescent Likelihood. D: . a set of binary sequences.. Coalescent genealogy: history with . Xe+trymethilamine. Mixtures using a . Micromegas. -TPC. D. C. Herrera, on behalf of the Zaragoza group. Universidad de Zaragoza, Spain . in . c. ollaboration with Lawrence Berkeley Lab, USA. TIPP Conference. These phenomena observed in Saccharomyces cerevisiae are highly conserved in eukaryotes, thus rendering yeast, which is easy to use, an essential model organism. Researchers identified and studied fun Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . General background to site-specific recombination . The lambda recombination system (more stealing from other organisms!). Potential advantages of using recombination for cloning. Adaptation of the lambda recombination system for efficient cloning – GATEWAY technology.