PPT-A New Model for Coalescent with Recombination

Zhi Ming Ma ECM2013 PolyU Email mazmamtaccn httpwwwamtaccnmembermazhimingindexhtml A New Method for Coalescent Processes with Recombination . Jelle Kaastra. with. . Ton . Raassen. , . Liyi. . Gu. , . Junjie. Mao, . Igone. . Urdampilleta. , . Missagh. . Mehdipour. SRON & Leiden University. Introduction. X-ray emitting plasmas everywhere:. Milky Way. Marina Berezina (Max Planck . IfR. ). Kevin Hardegree-Ullman (Univ. of Toledo). Yanina. . Metodieva. (Univ. . of . Sofia). Amanda . Kepley. (NRAO, GBT). Image Credits: www.otakupop.com, www.cv.nrao.edu. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . In the complex model we allow for differing defect and band occupation densities and calculate the recombination as. Where: . A. τ. = 1 / defect capture time (1/. τ. ). . B. = radiative constant . Secreted by B lymphocytes. Great diversity and specificity: >10. 9. different antibodies; can distinguish between very similar molecules. Tag particles for clearance/destruction. Protect against re-infection (vaccines). Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. CSE280. Vineet Bafna. Expectation, and deviance. Statements such as the ones below can be made only if we have an underlying model that suggests what we should expect. . Recombination rates vary dramatically across the genome. Gene Tree Probability. under the . Multispecies Coalescent . and its Application in the Inference of Population Tree. Yufeng. . Wu. Dept. of Computer Science & Engineering. University of Connecticut, USA. Xe+trymethilamine. Mixtures using a . Micromegas. -TPC. D. C. Herrera, on behalf of the Zaragoza group. Universidad de Zaragoza, Spain . in . c. ollaboration with Lawrence Berkeley Lab, USA. TIPP Conference. Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . Bull R, Hansman GS, Clancy LE, Tanaka MM, Rawlinson WD, White PA. Norovirus Recombination in ORF1/ORF2 Overlap. Emerg Infect Dis. 2005;11(7):1079-1085. https://doi.org/10.3201/eid1107.041273. R. ecombination. 2. . Site-Specific . R. ecombination. 3. DNA . Transposition. Homologous Recombination at the Molecular Level. DNA BREAKS ARE COMMON AND INITIATE RECOMBINATION. Recombination repair DNA breaks by retrieving sequence information from undamaged DNA. General background to site-specific recombination . The lambda recombination system (more stealing from other organisms!). Potential advantages of using recombination for cloning. Adaptation of the lambda recombination system for efficient cloning – GATEWAY technology. the attB1 & 2 sequences are relatively short and are therefore suitable for addition to gene-specific primers . After PCR amplification, fragment contains the attB1 and attb2 sequences, and can be used for recombination with a vector carrying the attP1 and atP2 sequences, and the addition of the BP clonase enzyme mix. .