PPT-Mitochondrial Disease & its Anesthetic Considerations

Stephen Okoth BSN SRNA Sr York College of PA Wellspan Health NAP Objectives Discuss the structure of the Mitochondrion Discuss the main function of the Mitochondrion Detecting and Diagnosing mitochondrial diseases. Developing Countries Regional Anesthesia Lecture Series. Daniel D. Moos CRNA, . Ed.D. . USA . moosd@charter.net. . Lecture 1. Soli . Deo. Gloria . Disclaimer. Every effort was made to ensure that material and information contained in this presentation are correct and up-to-date. The author can not accept liability/responsibility from errors that may occur from the use of this information. It is up to each clinician to ensure that they provide safe anesthetic care to their patients.. . Committee on Human Gene Editing: . Scientific, Medical and Ethical Considerations . Consensus Study Meeting #2 . February 11, 2016 . Philip E. Yeske, Ph.D.. Science & Alliance Officer. United Mitochondrial Disease Foundation. Stephen Okoth BSN, SRNA (Sr.). York . College of PA/. Wellspan. Health NAP . Objectives. Discuss the structure of the Mitochondrion. Discuss . the main . function . of the . Mitochondrion. Detecting and Diagnosing mitochondrial diseases. Anesthesia for a Muscle Biopsy. Case . You are assigned to do an anesthetic for a muscle biopsy. The patient is a 13 month old male toddler with delayed motor milestones. . H. e can not sit unsupported, roll over, cruise or walk yet. He was delivered at 35 weeks PCA and spent 1 week in the NICU for feeding difficulties. There were never any respiratory difficulties. Per the parents the toddler has not had any prior anesthetics. There is no family history of muscular weakness or any problems with anesthesia although mom tells you that she was adopted and knows nothing about her biological family.. Fahad Alqahtani. Supervisor: Dr. Ion Măndoiu. Associate Advisors: Dr. Mukul Bansal & Dr. Derek Aguiar. Computer Science & Engineering Department. University of Connecticut. Outline. Background. Steve Black, PhD. Co-Director. , Cardiovascular Discovery Institute & Mitochondrial Bioenergetics Core . Chief, Pulmonary Vascular Disease Program. Vascular Biology Center. Georgia Regents University. “ ASK THE MITO DOC ” QUESTIONS Q . Do you have any studies or information about the use of Botox in patients with mitochondrial diseases? A. I would OigOly douNP POMP POere’s Mny sucO sPudy. . Parts 1 & 2: A&A pages 100-116. Objective: To be able to safely and . efficiently operate an anesthetic . machine, and trouble shoot any . problems that may arise.. Purpose of the Anesthetic Machine. VBC-608. Unit- III. P.G.. 23.11.2020. 24.11.2020. Mitochondrial Diseases. The term mitochondrial cytopathy refers to a diverse group of inherited or acquired disorders.. It is heterogeneous group of disorders.. Mina . Marden. Mitochondrial DNA. Mitochondrial DNA. Entire genome: 3.0x10. 9. . bp. Mitochondrial genome: 16,569 . bp. How I compared it…. Which mitochondrial genomes?. Felis. . catus. Panthera. Vasili Chernishof, M.D.. Carl Lo, M.D.. Children’s Hospital Los Angeles. Updated 9/2019. Disclosures. No relevant financial relationships to report. Learning Objectives:. Identify anatomical and physiological perturbations that occur with mediastinal masses. Enterocolitis. Monica Williams, MD. Johns Hopkins School of Medicine. Updated 9/2019. Disclosures. No relevant financial relationships. Learning Objectives:. The learner will be able to identify key features of NEC. Human Errors. • Miscalculation of the drug dose; getting one decimal wrong can mean ten times of overdose that may induce severe toxic effect. • Mislabeling of the syringe, misfiling to a wrong vaporizer etc. may constitute severe hazard. Dr R P Pandey. IV. Onset is and peak effect is quick, effect is intense, duration of action short. IM. Onset in 10-15 min, peak effect is delayed, depends on tissue perfusion/drug absorption/metabolism.