PPT-Growth Factors and Receptor Tyrosine Kinases

RTKsHow do they work EGFR signaling and ras MAP k inase cascades PI3K PKB PLC g PTPs Protein Tyrosine Phosphatases Epidermal growth factor Neurotrophic growth factor NGF isolated from mouse. Kinase. Inhibitors. Charles Harrell. Outline of Material Presented. Definition of Cancer. Understanding . Kinases. Kinase. Inhibitor Functionality. Economic Considerations. Assigned Reading. Homework Questions. Cell Signaling and Signal Transduction: Communication Between Cells. Signal transduction. Extracellular ligand: 1st messenger. Autocrine: ligand binds to producing cell. Paracrine: ligand binds to a neighbor cell. BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. G Protein Coupled Receptor Pathways. G Protein Coupled Receptors. Seven membrane-spanning domain receptors. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). Be ready to answer!. 3.D.3 Signal Transduction. Signal transduction pathways link signal reception with cellular response.. Many chemical messengers cannot cross the plasma membrane. . Signal transduction . k. inase . i. nhibition. Danny Rayes . Epidermal Growth Factor Receptor. EGF + EGFR .  growth and proliferation. Mutant EGFR (no ligand) .  growth and proliferation. Inhibiting activating mutations. k. inase . i. nhibition. Danny Rayes . Lung Cancer and Epidermal Growth Factor Receptor. Lung cancer is a leading cause cancer-related death . Two types of lung cancer. Non small cell (NSCLC) 80-85%. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. snps. As Identified by Lee et al., 2012. Jennifer . Przybylo. Typical presentation. Treatment. Aspirin!. IV immunoglobulin G. BUT…. . “Two . new susceptibility loci for Kawasaki disease identified through genome-wide association . OBJECTIVES:. Explain why the endocrine system is so closely related to the nervous system.. Distinguish between an endocrine gland and an exocrine gland.. Define the term . hormone and explain its general characteristics.. Dr. . Parastoo. . . Rostami. Associate of professor of pediatric endocrinologist. Tehran university . Children’s medical center. Epidemiology . Achondroplasia. is the most common form of human dwarfism. . The T-cell antigen receptor (TCR). The TCR is a complex of eight . transmembrane. proteins. The . خ± . and . خ² . chains form a disulfide-linked (. Sâ. €”S) dimer that is responsible for the recognition of antigenic peptides bound to class I and class II major . Protein . kinase. A . protein . kinase.  is a . kinase.  enzyme that modifies other proteins by chemically adding phosphate groups to them (. phosphorylation. ). . Phosphorylation. usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. .