PPT-Growth Factors and Receptor Tyrosine Kinases

RTKsHow do they work EGFR signaling and ras MAP k inase cascades PI3K PKB PLC g PTPs Protein Tyrosine Phosphatases Epidermal growth factor Neurotrophic growth factor NGF isolated from mouse. Kinase. Inhibitors. Charles Harrell. Outline of Material Presented. Definition of Cancer. Understanding . Kinases. Kinase. Inhibitor Functionality. Economic Considerations. Assigned Reading. Homework Questions. Cell Signaling and Signal Transduction: Communication Between Cells. Signal transduction. Extracellular ligand: 1st messenger. Autocrine: ligand binds to producing cell. Paracrine: ligand binds to a neighbor cell. BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. G Protein Coupled Receptor Pathways. G Protein Coupled Receptors. Seven membrane-spanning domain receptors. k. inase . i. nhibition. Danny Rayes . Epidermal Growth Factor Receptor. EGF + EGFR .  growth and proliferation. Mutant EGFR (no ligand) .  growth and proliferation. Inhibiting activating mutations. DERMAL COLLAGENS. “Structural” component of skin. Comprises ~ 70 – 80 % of dermis. Mostly Type I and Type III in humans. Some properties of skin collagens. Skin collagens belong to a genetically distinct group of structural proteins. . . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist and Neurone blockers Dr. ISHOLA I.O. PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound, NA, AD, DA, ISOP snps. As Identified by Lee et al., 2012. Jennifer . Przybylo. Typical presentation. Treatment. Aspirin!. IV immunoglobulin G. BUT…. . “Two . new susceptibility loci for Kawasaki disease identified through genome-wide association . OBJECTIVES:. Explain why the endocrine system is so closely related to the nervous system.. Distinguish between an endocrine gland and an exocrine gland.. Define the term . hormone and explain its general characteristics.. endosome. GA. IAA. BR. ABA. Brassinosteroid. LRR – . kinase. domain. Cytokine. Two components histidine kinases. Degradation. (repressor). Sequester. (. phosphatase. ). Auxin. F-box E3 . ubiquitin. The Mitosis Puzzle. Lay blank sheet lengthwise .. Write Interphase, Prophase, Metaphase, Anaphase, & . Telophase. across the top of the sheet.. Cut out the cell diagrams and tape/glue them across the top under the appropriate phase label.. İhsan . ÇALIŞ. References. . R. . Hänsel. &O. . Sticher. , . Pharmakognosie. , . Phytopharmazie. , . Springer. , . Heidelberg. 2007 . J. . Bruneton. , . Pharmacognosy. : . Phytochemistry. - . Pharmacodynamics. D-R Interact.ions and Pharmacodynamics. Pharmacodynamics. . Describes the actions of drugs on the body and the influence of drug . concentration on the magnitude of the response. The T-cell antigen receptor (TCR). The TCR is a complex of eight . transmembrane. proteins. The . خ± . and . خ² . chains form a disulfide-linked (. Sâ. €”S) dimer that is responsible for the recognition of antigenic peptides bound to class I and class II major .