PPT-Four models of the helix, showing different aspects of its structure. (a) Formation of

α helix The planes of the rigid peptide bonds are parallel to the long axis of the helix depicted here as a vertical rod b Ballandstick model of a right handed α helix showing the intrachain. DNA is composed of polynucleotide chains. The helical structure of . DNA. Formation of Nucleotides. Structure of polynucleotide polymer. Each base has its preferred . tautomeric. form. Purine. and . C483 Spring 2013. 1. Which . statement is false about a globular protein that performs its biological function as a single independent polypeptide chain?. A. ) Its tertiary structure is likely stabilized by the interactions of amino acid side chains . 2.6 Structure of DNA & RNA. Understandings:. The nucleic acids DNA & RNA are polymers of nucleotides.. DNA differs from RNA in the # of strands normally present, the base composition & type of pentose.. THINK ABOUT IT. The DNA molecule must somehow specify how to assemble proteins, which are needed to regulate the various functions of each cell.. What kind of structure could serve this purpose without varying from cell to cell?. The helical structure of . DNA. Formation of Nucleotides. Structure of polynucleotide polymer. Each base has its preferred . tautomeric. form. Purine. and . Pyrimidine. Base . tautomers. ; are frequent sources of errors during DNA synthesis. Biomolecular Structure. Protein Structure. 9/25/09. www.optics.rochester.edu/.../image007.gif . Chemical Biology 03. BLOOD. Biomolecular Structure . Protein Structure. Lecture 8: 9/25/09. Hierarchy . College . of Education . Salahaddin. . University. Kirkuk . Road . Erbil-Iraq . Tel. .: . 07504095454. Research . Fellow. . Manchester Fungal Infection Group . The . University of Manchester . Institute . 1 Helices From Readily in Biological StructuresA helix is generated simply by placing many similar subunits next to each other, each in the same way strictly related repeated relationship to the one b Some of the slides are adapted from Dr. Dong Xu’s lecture notes. Why secondary structure prediction?. Accurate secondary structure prediction can be an important information for the tertiary structure prediction. . What we hope to learn. . The basic building blocks: amino acids. Secondary structure. Forces that drive folding. Motifs or supersecondary structure. Domains. Finding out more about structures. Illustrations using A.  peptides. . and PrP. C . as examples. Global Structure of amyloid fibrils. diameter = 4-12 nm (electron microscopy). cross-. b . structure (strands perpendicular to long axis of fibril) . Mini whiteboards. Sweets for DNA model (see link to sheet on slide). Speakers. Practical ‘DNA your onions’: blender, knife, white tile, water bath (60. o. C), ice, thermometer, beakers, funnel, filter paper, syringe, boiling tube, glass rod, pipette, protease, washing up liquid, salt, 95% ice cold ethanol. sontum@middlebury.edu. Chapter 9: Developing Bioinformatics Computer Skills. Cynthia Gibas & Per Jambeck. Visualizing Protein Structures. and Computing. Structural Properties. Visualizing Protein Structures. Max Perutz. LMB, Cambridge. Introduction to Structural Biology. Amino acids and nucleotides. Proteins 1. o. , 2. o. , 3. o. and 4. o. structure. Nucleic Acids: Structural Parameters. Found in nature.