Supranuclear Palsy an underestimated condition E Del Prete L Tommasini D Frosini S Mazzucchi A Bruno U Bonuccelli R Ceravolo DIPARTIMENTO DI MEDICINA CLINICA E SPERIMENTALE UO NEUROLOGIA UNIVERSITÀ ID: 1047736
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1. Language disorders in Progressive Supranuclear Palsy: an underestimated condition? E. Del Prete, L. Tommasini, D. Frosini, S. Mazzucchi, A. Bruno, U. Bonuccelli, R. Ceravolo DIPARTIMENTO DI MEDICINA CLINICA E SPERIMENTALE, U.O. NEUROLOGIA, UNIVERSITÀ DI PISA, PISA
2. PSP is characterized by specific neuropsychiatric and cognitive dysfunction. The pattern of early cognitive impairment in PSP is usually a dysexecutive frontal syndrome but language domains could also be affected. Cognitive dysfunction is now considered one of four core features and speech/language deficit is gaining more relevance.Hoglinger, Movement Disorders, 2017 New criteria for clinical diagnosis of PSP have recently been published by the Movement Disorders Society. Background:
3. we aimed to investigate executive functions and languages abilities in PSP patients and in Progressive Supranuclear Palsy subgroups [PSP-Richardson’s Syndrome (PSP-RS) and PSP-non-RS] according to new Movement Disorders Society criteria. PSP-RS PSP with Richardson’s syndromePSP-OM PSP with predominant ocular motor dysfunctionPSP-PI PSP with predominant postural instability PSP-P PSP with predominant parkinsonism PSP-F PSP with predominant frontal presentation PSP-CBS PSP with predominant CBSPSP-PGF PSP with progressive gait freezingPSP-SL PSP with predominant speech/ language disorderPSP-RS PSP-non-RS Objectives:
4. 22 PSP patients15 PSP-RS7 PSP-non-RS (3 PSP-CBS, 3 PSP-P, 1 PSP-SL)FAS, Semantic Fluency Test, AAT naming test and SAND (Screening for Aphasia in NeuroDegeneration)Global cognitive status (MMSE), Attention & Working Memory (Digit Span Foward & Backward), Executive Functions (FAB) Languages Abilities Clinical EvaluationPSP-Rating ScaleApathy Evaluation Scale; Beck Depression Inventory IIMethods
5. Results
6. Results***The presence of language disorders could be part of PSP-RS phenotype. In our cohort PSP-RS show simplified syntactic structures with paucity of used verbs even if the impairment does not meet criteria for definite agrammatism.
7. Grazie per l’attenzione