PPT-Update on 100,000 Genomes Project and look ahead to Genomic Medicine Service

Chris Wragg Lead Cancer Scientist SWGLH 6 th March 2019 Contents 100000 Genomes Project National update Update on the future genomic medicine service National delivery of 100000 Genomes . Fikret Isik. Associate . Professor. September 16, 2013. Genomic BLUP - UofCopenhagen. 1. Cooperative Tree Improvement Program. North Carolina State University, Raleigh, . USA. Outline. Background. Realized genomic relationships. National Aeronautics and Space Administration 300,000,000900,000,0001,500,000,0002,100,000,0002,700,000,0003,300,000,0003,900,000,0004,500,000,000 5,100,000,0005,700,000,000kilometers 0 LG-2009-09-570 National Aeronautics and Space Administration 300,000,000900,000,0001,500,000,0002,100,000,0002,700,000,0003,300,000,0003,900,000,0004,500,000,000 5,100,000,0005,700,000,000kilometers 0 46 0.000.000.000.000.000.000.000.000.000.000.000.000.010.000.000.000.010.000.000.000.000.01160.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.000.00170.000.000 Comparative genomics of sponges, sea anemones, and multicellular pancakes. Mansi Srivastava. Rokhsar Lab, Department of Molecular and Cell Biology, UC Berkeley. Reddien Lab, Whitehead Institute for Biomedical Research. Genomic Medicine. In announcing on June 26, 2000, that the first draft of the human genome had been achieved, President Clinton said it would “revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.”. Validation of genomic predictions and genomic reliability Mel Tooker and Paul VanRaden USDA, Agricultural Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD, USA melvin.tooker@ars.usda.gov Hardison. . Genomics 2_2. 1/7/15. 1. Y Chromosome. 3 billion bp = 3 Gb. Chr1 247 Mb. Chr12 132 Mb. Chr22 50 Mb. A human . genome (. male). The . genome. is . all the DNA. in a cell.. All the DNA on all the chromosomes. Circularly Permuted Genomes. Some phages have circularly permuted genomes. This means a linear concatamer of phage DNA is synthesized, used to fill a phage head, then cut when the head is full. Generally, one head will fit more than 100% of a genome, say, 103-110%. This ensures that wherever the DNA is cut, at least one working copy of each gene is present.. Dina Paltoo, Ph.D., M.P.H.. NIH Office of Science Policy. Laura Lyman Rodriguez, Ph.D.. National Human Genome Research Institute. October 4, 2017. Housekeeping. Participants must register to join the webinar. ETH Zürich. October 1, 2015. Mathias Humbert . Joint . work. with Erman Ayday, Jean-Pierre Hubaux, . Kévin Huguenin, Joachim Hugonot, Amalio Telenti. (. Human. ) System Security. 0. 1. 0. 0. 1. 1. Dr. Breno Fragomeni. Assistant Professor. Animal Science - UConn. Where are the labels?. Introduction . Why genomic prediction?. Higher accuracy. Shorter generation interval . Higher genetic gain. Genetic gain per year. Working together towards a common strategy . Overview. Implementing Genomic Medicine. Vision. Scope & Purpose. Background. SNOMED CT Strategy . (what & how). Strategic objectives. Next steps. Paul VanRaden and Jeff O’Connell*. Animal Genomics and Improvement Laboratory. Agricultural Research Service, USDA, Beltsville, MD. *University of Maryland-Baltimore. paul.vanraden@ars.usda.gov. Topics.