PPT-Sepsis Biomarkers Daniel B. Ambrus, MD MSc

Assistant Professor Department of Hospital Medicine SLAM Sepsis Symposium October 31 st 2018 Disclosures I have no actual or potential conflicts of interest with regard to this programpresentation. Laura Evans, MD MSc. Medical Director of Critical Care. Bellevue Hospital. NYU School of Medicine. Disclosures. No conflicts of interest to disclose. Outline. Burden of sepsis. Surviving Sepsis Campaign. Adult Inpatients. Learning objectives. Recognise that sepsis . i. s a medical emergency. Identify the risk factors, signs and symptoms. Outline the escalation of the septic patient . Define the . initial management actions. program . (general overview). add . LHD and/or hospital name. Aims. Provide an overview of the SEPSIS KILLS program . and its impact in this LHD/facility. Outline the elements of the inpatient SEPSIS KILLS program. EM Student Lecture Series. CASE STUDY. A 53-year old woman presents complaining of several days of fever, generalized malaise, nausea & vomiting. She has a PMH of diabetes and HTN and takes . Glucophage. FAINELLI . Manon. BOGÓ . Ákos. . Szakács . Júlia . M.D. . . Department of Pathophysiology. Numbers…. Cardiovascular diseases . The most frequent cause of death. 7.5 millions of death/ year. Important concerns in developed countries. Brooke Benninger, lauren lucas, Stephanie lee, jose alvarez . Introduction to patient . Personal Data . Mr. Chris McKinley, 37 . y.o. .. Came in weighing 325# and is 5’10”. Office manager for real estate office . Stage 1. Source: world-sepsis-day.org . What is Sepsis?. Source: world-sepsis-day.org . Sepsis at a Glance. Sepsis is a . medical emergency . . . . . Source: . Advisory Board Company: “Why sepsis screening isn't one-size-fits-all” . COI Disclosures. Evans – Nothing to disclose. Thank You. Guidelines panelists. Group Heads. Methodologists. SCCM and ESICM . Participating societies. Reviewers. Dr. Phil Dellinger. Ms. Deb . Mcbride. Early recognition of Sepsis. Early Goal Directed Therapy . CASE. 6. 4yr . Samoan male. 24 . hr. . Fever, productive cough, SOB . and . delirium. Initial . Obs. HR 162, RR . 40, . sats. . 90% . on 15l, BP . Filipa Mendes. Center. for Nuclear Sciences . and. Technologies. IST, Universidade de Lisboa .  . Summer school . Development and Pre-clinical Evaluation of Radiopharmaceuticals. Molecular . and. Cell . Optimist. Department of Biochemistry, Molecular Biology and Biophysics. Institute on Biology of Aging and Metabolism. lniedern. @. umn.edu. Utility of mice in biomarker discovery. Strength . of mice. a measurable indicator . that . can . tell . us something about a person’s health or disease . state, for example, . disease (pathological) processes in the body, for example, disease stage. , . biological processes in the body (heart rate, blood pressure, temperature), . Leyen. Vu, DO. Sept. 8. th. , 2018. WSU Cougar Health Services. WSU Athletics Team Physician. Objectives. Need for objective measures for concussion. Identify characteristics of ideal serum biomarkers for concussion. Nfl. =neurofilament light; PDGFR. . =. platelet-derived growth factor receptor beta. ; . PET=positron emission tomography; p-tau=phosphorylated tau; RT-. QuIC. =real-time quaking-induced conversion; SNAP-25=.