PPT-Atazanavir versus Lopinavir-ritonavir in Prior PI Failure

AI424043 Study Atazanavir vs Lopinavirritonavir in Previous PI Failure AI424043 Study Design Source Cohen C et al Curr Med Res Opin 200521 168392 Atazanavir 400 mg once daily 2 NRTIs. OBV/PTV/r . + . DSV . + RBV. OBV/PTV/r + . DSV . + RBV. Randomisation**. 1 : 1. Open-label. 18-70 years. HCV genotype 1. Naïve or pre-treated. Cirrhosis*. Child-Pugh A < 7. HCV RNA ≥ 10,000 IU/ml. HIV Malaria Co-infection. M . Lamorde. MRCP, PhD. Malaria: major cause of morbidity and mortality in tropics. Treatment: artemisinin derivatives are critical for eradication of . plasmodium falciparum . SAPPHIRE-I. Phase 3. . Treatment. . Naïve. Feld JJ, et al. N . Engl. J Med. 2014;370:1594-1603.. Source: Feld JJ, et al. N . Engl. J Med. 2014;370:1594-1603.. 3D . (Paritaprevir-Ritonavir-. Ombitasvir + Dasabuvir) + Ribavirin in GT1. OBV/PTV/r . + . DSV . + RBV. OBV/PTV/r + . DSV . + RBV. Randomisation**. 1 : 1. Open-label. 18-70 years. HCV genotype 1. Naïve or pre-treated. Cirrhosis*. Child-Pugh A < 7. HCV RNA ≥ 10,000 IU/ml. . and Dasabuvir +/- . RBV in . GT1b. PEARL-II. Phase . 3. Treatment. . Experienced. Andreone. P, . et al. . Gastroenterology. 2014;147:359-65.. Source: . Andreone. P, et al. Gastroenterology. 2014;147:359-65.. . and Dasabuvir + RBV in GT1. SAPPHIRE-I. Phase 3. . Treatment. . Naïve. Feld JJ, et al. N . Engl. J Med. 2014;370:1594-1603.. Source: Feld JJ, et al. N . Engl. J Med. 2014;370:1594-1603.. Ombitasvir-Paritaprevir-Ritonavir . N = 45. N = 49. W24. W16. MK3. > . 18 years. HCV infection. G. enotype 1. Relapse after LDV/SOF or EBR/GZR. Compensated . cirrhosis** . allowed. Well-controlled HIV co-infection allowed. Randomisation. in pregnancy: . . preterm delivery rates, . infant outcomes and . virological efficacy.. Dr Melissa Perry. Guy’s & St Thomas’ NHS Foundation Trust. London. United Kingdom. Low rates of mother-to-child transmission of HIV . TARV. JHÓSEP ANDRÉS BLANCO MEJÍA. Interno Junior Farmacología Clínica. Universidad de La Sabana. CONTENIDO. Presentación de caso clínico. Consideraciones . farmacoterapéuticas. Recomendaciones. Paul Reynolds, PharmD, BCCCP. Matthew Miller, PharmD, BCIDP. Gina Moore, PharmD, MBA. March 20, 2020. Learning Objectives. Identify the unique clinical and epidemiological characteristics of Coronavirus (COVID-19) in the spectrum of viral clinical illnesses and previous Coronavirus (SARS, MERS) and non-Coronavirus (influenza, common cold) related illnesses. Lopinavir. -RTV in Treatment Experienced. TITAN Trial. Darunavir/. r . versus Lopinavir/r in Treatment-Experienced . TITAN. : Study Design. Source: . Madruga. JV, et al. Lancet. 2007;370:49-58. . Darunavir. Ombitasvir + . Dasabuvir) +/- . RBV in . GT1b. PEARL-II. Phase . 3. Treatment. . Experienced. Andreone. P, . et al. . Gastroenterology. 2014;147:359-65.. Source: . Andreone. P, et al. Gastroenterology. 2014;147:359-65.. R. itonavir to Raltegravir. SWITCHMRK 1 & 2 Trials. Switching from Lopinavir-Ritonavir to Raltegravir. SWITCHMRK 1 & 2 Trials: Study Design. Source: . Eron. JJ, et al. Lancet. 2010;375:396-407.. Study 105. Atazanavir + [Cobicistat or Ritonavir] + TDF-FTC (Phase 2). Study 105: Study Design. Source: . Elion. R, et al. AIDS. 2011;25:1881-6. . Background. : Randomized, partially placebo-controlled, double-blind phase 2 trial to compare the safety and efficacy of cobicistat and ritonavir as pharmacokinetic enhancers administered with atazanavir and fixed-dose tenofovir DF-emtricitabine in treatment-naïve adults with HIV infection.