Amanda Wilkins Scientists Reverse Autism Symptoms in Mice SciTechDaily November 22 2013 Image available at httpscitechdailycomscientistsreverseautismsymptomsinmice Autism Impact Activity ID: 315343
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Autism Spectrum Disorders (ASD) Presented by:
Amanda Wilkins
Scientists Reverse Autism Symptoms in Mice.
SciTechDaily
. November 22, 2013. Image available at: http://scitechdaily.com/scientists-reverse-autism-symptoms-in-mice
/Slide2
Autism Impact ActivityDemographicsTypes of DisordersEtiology &
PathophysiologySigns & SymptomsDiagnosis & Lab ValuesNutritional Status TreatmentsNutrition Care ProcessOverviewSlide3
What does it feel like to be autistic?Sensory Overload
Activity Time1. Jiron
M, Harris MJ, Kinder M. Interacting with Autism. Health Research and Quality. Available at: http://vimeo.com/52193530. Slide4
1 in 68 children; 1 in 42 boys1 in 189 girlsFive times more common in boys
$60,000 cost for a family per yearAll racial, ethnic, and socioeconomic groups; Caucasians are highestAbout 50% of children have at least average intellectual ability25% with ASD are non-verbalDemographics
2.
Baio
, J. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years – Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010. Center for Disease Control and Prevention.
Morbidity and Mortality Weekly Report.
Available at:
www.cdc.gov/mmwr/preview/mmwrhtml/ss6302a1.htm?s_cid=ss6302a1_w
. Accessed on March 20, 2013.
Slide5
Classic AutismRett Syndrome
Pervasive Developmental Disorder – Not Otherwise Specified (PDD-NOS)Asperger’s SyndromeChildhood Disintegrative DisorderTypes of ASD
3. Autism
Spectrum Disorders.
American Psychiatric Publishing Association.
2013. Available at: http://www.dsm5.org/Documents/Autism%20Spectrum%20Disorder%20Fact%20Sheet.pdf. Accessed on March 20, 2014.
4.
Boyse
K. Autism, Autistic Spectrum Disorders (ASD) and Pervasive Developmental Disorders (PDD). University of Michigan Health System. Available at: http://www.med.umich.edu/yourchild/topics/autism.htm#ad.
5. Autism Fact Sheet. National Institute of Neurological Disorders and Stroke. Available at: http://www.ninds.nih.gov/disorders/autism/detail_autism.htm#243573082Slide6
“John's early history was totally normal. By age 2 he was speaking in sentences, and he made frequent eye contact with his parents, and his older brother. At age 3 1/2 he became extremely anxious, frequently awaking at night terrified. During the day he would cry inconsolably for long periods of time, often repeating the phrase, “it hurts, it hurts, make it go away”. After a month, his parents describe a steep decline in his communication skills. He began to flap his hands, to soil himself, and had no interest in social interaction. Extensive medical examinations were conducted at 2 pediatric hospitals, failing to reveal anything that might explain the regression. At follow-up at age 12 he still was not speaking, apart from an occasional single word, and had been placed in a school for the severely
disabled.”Why did they switch?6. Autism Program at Yale. Yale School of Medicine. August 02, 2011. Available at: http://medicine.yale.edu/childstudy/autism/information/cdd.aspx.Slide7
GeneticDNA changesVaccines Brain Connections and growthImmune System
Environmental factorsSerotonin levelsEtiology7. Autism FAQ. Autism Speaks. Available at: www.autismspeaks.org/what-autism/faq. 5. Autism Fact Sheet.
National
Institue
of Neurological Disorders and Stroke.
Available at:
http
://
www.ninds.nih.gov/disorders/autism/detail_autism.htm
.
8. About Autism. Autism Society. Available at:
http
://
www.autism-society.org/about-autism/causes
.
9.
Gotts
S,
Matin
A. Social Brain Circuits Disrupted in Autism.
National Institute of Mental Health.
July 19, 2012. Available at:
http
://
www.nimh.nih.gov/news/science-news/2012/social-brain-circuits-disrupted-in-autism.shtml
. Accessed on March 10, 2014.
10. Casanova MF, El-
Baz
AS, and
Suri
JS. 2013.
Imaging the brain in autism
. New York, NY: Springer
.
Available at:
http://
link.springer.com.ezproxy.memphis.edu/chapter/10.1007/978-1-4614-6843-1_2/fulltext.html
.
11.
Coleman, M. (2005). The neurology of autism. New York: Oxford University Press
Available at: http://web.a.ebscohost.com.ezproxy.memphis.edu/ehost/ebookviewer/ebook/bmxlYmtfXzE0MzM0NV9fQU41?sid=5a071554-54d6-4b53-a187-917104eb9a05@sessionmgr4003&vid=1&ppid=pp_79&format=EB&nobk=ySlide8
ASD vs. Healthy Brain
9. Gotts S, Matin A. Social Brain Circuits Disrupted in Autism. National Institute of Mental Health. July 19, 2012. Available at: http://www.nimh.nih.gov/news/science-news/2012/social-brain-circuits-disrupted-in-autism.shtml.Slide9
Anatomy & Physiology
12. Treatment for Autism. Brain Performance Center. 2012. Available at: http://www.thebrainperformancecenter.com/conditions-and-symptoms/autism-spectrum/.Slide10
CommunicationDelayed response to nameBabbles then stops talking
Social BehaviorLonelyMisses social cuesRepetitive BehaviorsOther Physical andMedical ConditionsSigns & Symptoms
13. Associated Medical Conditions.
Autism Speaks. Available at:
www.autismspeaks.org/what-autism/symptoms..
5. Autism
Fact Sheet.
National
Institue
of Neurological Disorders and Stroke.
Available at:
http://www.ninds.nih.gov/disorders/autism/detail_autism.htm
.
14. DSM-5 Autism Spectrum Disorder Guidelines & Criteria Examples. Available at: http://
depts.washington.edu/dbpeds/Screening%20Tools/DSM-5(ASD.Guidelines)Feb2013.pdf.
Autism Spectrum Disorder. Dream Health. Image available at: http
://
www.dreamresearchgroup.com/2014/02/autism-spectrum-disorder.html. Slide11
Modified Checklist of Autism in ToddlersNo confirmed medical testMultidisciplinary team
Genetic testingSleep difficulties testingHearing and VisionDiagnosis
15. How is Autism Diagnosed? Autism Speaks. 2014. Available at:
http://www.autismspeaks.org/what-autism/diagnosis
.
16. About Autism Diagnosis. Autism Society. 2013. Available at: http
://
www.autism-society.org/about-autism/diagnosis/.
17.
Tongerloo
M,
Bor
H,
Lagro
-Janssen A. Detecting Autism Spectrum Disorders in the General
Practitioner'S
Practice.
Journal Of Autism & Developmental Disorders
[serial online]. August 2012;42(8):1531-1538. Available from:
OmniFile
Full Text Mega (H.W. Wilson), Ipswich, MA. Accessed
March
2,
2014
18.
Bridgemohan
C, Hanson E, and Spence S.
Autism spectrum disorders (ASDs).
Boston Children’s Hospital.
Available
at:http
://
www.childrenshospital.org
/health-topics/conditions/autism-spectrum-disorders.Slide12
Lab Values
19.Biochemical and Nutrient Issues. Academy of Nutrition and Dieitetics Nutrition Care Manual. 2014. Available at: http://www.nutritioncaremanual.org/content.cfm?ncm_content_id=110027&highlight=autism
ASD
Control
Urinary Protein
103.2 mcg/
mL
64.5 mcg/
mL
Urinary Sulfites
107
nmol
/
mL
2.1
nmol
/
mL
Urinary Sulfates
6,819
nmol
/
mL
3,030
nmol
/
mL
Cysteine
(s-amino acid)
Can be lacking
Normal
Vitamins – B
Lower
Normal
Omega-3 FAs
Lower
NormalSlide13
Early InterventionMedicationsAntipsychotic
AntidepressantStimulantBehavior and Communication ApproachesDietary ApproachesComplementary and Alternative MedicineParentsTreatments
20. Autism Spectrum Disorder (ASD) Treatment.
Centers for Disease Control and Prevention.
Available
at:
http://
www.cdc.gov/ncbddd/autism/treatment.html
.
21. A Parent’s Guide to Autism Spectrum Disorders.
National Institute of Mental Health.
Available at: http
://
www.nimh.nih.gov/health/publications/a-parents-guide-to-autism-spectrum-disorder/index.shtml.
22.
Rokuskie
P.,
Ignasiak
M, and Vega V. The Parent’s Perspectives on Autism Spectrum Disorders.
ReachMD
. 2014. Available at: http
://www.reachmd.com/xmsegment.aspx?sid=6812&&
17&utm_source=ReachMD+Distribution&utm_campaign=bb423552db-ReachMD_Newsletter_09_09_2013&utm_medium=email&utm_term=0_9f0d11fa3d-bb423552db-13524921.Slide14
Thinner BonesGI discomfortAdding vitamins and minerals
Gluten-Free or Casein-Free dietsMost often combined Gluten and Diary Free diets Nutritional Treatment23.
Winburn
E, Charlton J,
McConachie
H, et. al. Parents’ and Child Health Professionals’ Attitudes Towards Dietary Interventions for Children with Autism Spectrum Disorders.
J Autism Dev Disorders.
September 9, 2013
.
4
4:747–757
.
DOI
10.1007/s10803-013-1922-8.
19. Biochemical and Nutrient Issues.
Academy of Nutrition and
Dieitetics
Nutrition Care Manual.
2014. Available at: http
://
www.nutritioncaremanual.org/content.cfm?ncm_content_id=110027&highlight=autism.
24. Nutritional Therapy.
Eunice Kennedy Shriver National Institute of Child Health and Human Development.
January 16, 2014. Available at: http://www.nichd.nih.gov/health/topics/autism/conditioninfo/Pages/nutritional-therapy.aspxSlide15
Each child is uniqueUse a multidisciplinary team Look for addition genetic disorders
Try a gluten-free, caesin-free diet for nutritional supportMake the child as comfortable as possible throughout the processNutrition Care Process
25. Goldstein, S., &
Naglieri
, J. A. (2013). Interventions for autism spectrum disorders: Translating science into practice. New York, NY: Springer.
http://www.nutritioncaremanual.org/content.cfm?ncm_content_id=110027&highlight=autismSlide16
Thank You!
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