PPT-Immunity and Tumors

Cancer Immunotherapy Immunity and Tumors 1890s Coley treats patients with bacterial extracts 19501960s Burnet and Thomas Immunesurveillance Hypothesis Major function of the immune system is to recognize and destroy arising malignantly transformed cells. Jagan Sastry, PhD. Professor, Department of Immunology. Professor, Department of Veterinary Sciences . The University of Texas MD Anderson Cancer Center. Associate Development Core Director . UT-Baylor . Tumor antigens. Immune system’s reaction to tumor antigens. How tumors . evade. . the. immune system. Immunologic approaches to treatment of cancer. Cancers . arise. from . the. . uncontrolled. Begin . Dermoid. cyst. Mucocele. Hemangioma. Lymphangioma. Malignant . rabdomyosarcoma. Benign tumors of the orbit . can develop from infancy and grow rapidly or slowly. It can be superficial and easily identifiable by external presentation, palpation and x – rays or CT scan . In short, it is safe to state that immunity refers to the rules and principles that govern diplomatic relations between states and other entities with legal personality within the international system.. Begin . Dermoid. cyst. Mucocele. Hemangioma. Lymphangioma. Malignant . rabdomyosarcoma. Benign tumors of the orbit . can develop from infancy and grow rapidly or slowly. It can be superficial and easily identifiable by external presentation, palpation and x – rays or CT scan .  . Immunity . is defined as the capacity of the body to resist the pathogenic agents. It is the ability of the body to resist the entry of . different types of . foreign bodies like bacteria, . virus, . The term Immunity has traditionally referred to the resistance exhibited by the host towards injury caused by microorganism and their product.. However, protection against infectious disease is only one of many consequences of immune response, which in its entirety is concerned with the reaction of the body against any foreign antigen.. animal oncology . DR. KAUSHAL KUMAR. Assistant Professor & Head. Department of Veterinary Pathology. Bihar Veterinary College, BASU, Patna. Put on your thinking cap. Can you be immune to cancer?. of certain substances in . the blood and lymph stream. . These . substances are known as antibodies. . This immunity is inborn. . . Antigens. , the foreign substances that attack the body, stimulate the production of antibodies. . The resistance that an individual acquires during life by recognising and selectively eliminating specific foreign molecules is known as acquired immunity.. This is displays four characteristic features:. Assistant Professor – Department of Pathology. http://. fac.ksu.edu.sa. /. mariaarafah. /courses. Objectives. Upon completion of this lecture, students should be able to. :. Appreciate . how the anatomy of the skull and the spinal column influences the prognosis of both benign and malignant primary CNS tumors. Features of adaptive immunity:. Adaptive immunity is characterized by the following:. 1. Antigenic specificity: (. highly specific).. 2. Diversity : . ( each antigen there is specific T-cell and B-cell for it).. Its . how your body recognizes and defends itself against bacteria, viruses, and substances that appear foreign and harmful.. IMMUNE SYSTEM- . Its a network of tissues and organs containing cells that recognize foreign substances in the body and destroy . Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. .