PDF-The effects of a serotonin 2C receptor agonist on endogenous and amp

antagonists increase striatal DA 2A antagonists attenuate amphetamineinduced DA elevation in the striatum HYPOTHESIS The effects of 5HT agonists will mirror those previously shown for 5HT ant. Pharmacodynamics. Pharmacodynamics. The study of the biochemical and physiologic effects of drugs and the molecular mechanisms by which those effects are produced . The study of what drugs do to the body and how they do it . . Dr. Sameer Al- Rekabi. . Autacoids = local . hormones. DEFINITION. These are heterogeneous group of chemical substances with wide spectrum of biological effects , synthesized by different tissues and exerting local effect with no or very minute serum level.. A Selective Overview. Carl Rosow, M.D., Ph.D.. Disclosures. Consultant – Salix Pharmaceuticals. Topics for Today. Pharmacodynamics. Receptors, potency, efficacy. Agonists, antagonists. The dose response curve. Objectives. Monoamines and Depressive States. Genotype, Endophenotype, Phenotype Hypothesis. Implications for Drug Design. Focusing on Serotonin Receptor-Specific Antidepressants. Focusing on Serotonin Receptor-Specific Antidepressants: SARI and NASA . Jessica Tagerman, . PharmD. , . RPh. Pharmacokinetics & pharmacodynamics. Pharmacodynamics: What the drug does to the body. Pharmacokinetics: What the body does to the drug. pharmacodynamics. “What the drug does to the body”. Lectures. Drug Mechanisms. Receptor Interactions. Pharmacokinetics. Pharm definitions and drug selectivity. Drug= A chemical substance that interacts with a biological substance to produce a physiological effect. Pain. . Pain. persists Pain persists. or increases or increases. 1. . Non. -. opioid. ± adjuvant. 2. Weak . opioid. ± non-. opioid. ± adjuvant. 3. Strong . opioid. Anna Maria Nardiello. 1,. *, Lucia Sessa. 1,2. , Jacopo Santoro. 1. and Stefano Piotto. 1,2. 1. . Department of Pharmacy, University of Salerno, . Fisciano. , 84084, Italy. 2. . Research. Centre for . Graded Dose-response Relationships. Agonist . drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 . receptors . of the heart). The magnitude of the drug effect depends on the drug concentration at the receptor site, which, in turn, is determined by both the dose of drug administered and by the drug’s pharmacokinetic profile, such as rate of absorption, distribution, metabolism, and elimination. autocoids. ) or local hormones are substances produced by different tissues throughout the body . and . act locally . in . brief duration . to . modulate the activity of smooth muscles, . nerves, . platelets, and other tissues. Several autacoids also serve as neurotransmitters in the central nervous system (CNS) or enteric nervous system. . Archana Vidya Boopathy,. 1. Anurag Nekkalapudi,. 1. Bhawna Sharma,. 1. Sophie Schulha,. 2. . Raphaela. Wimmer,. 2. Debi Jin,. 1. Janette Sung,. 1. Jeffrey Murry,. 1. Mark Nagel,. 1. Brian Carr,. Ketamine and PCP . – glutamate receptor antagonists. LSD . – serotonin receptor agonist. Alcohol. – GABA-A and . GABA-B receptor agonist (also NMDA receptor antagonist). MDMA. – increases activity of serotonin, dopamine and noradrenaline by enhancing their release and/or inhibiting reuptake. Pharmacodynamics. Dennis Paul, Ph.D.. dpaul@lsuhsc.edu. Learning Objectives:. Understand the theoretical basis of drug-receptor interactions.. Understand the determinants and types of responses to drug-receptor interactions.. Graded Dose-response . Relationships:. Agonist drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 receptors of the heart). .