PPT-CARCINoGENESIS

Dr Fahd ALMULLA Phase II 2009 Lecture available httpwwwalmullaorg Target knowledge What is carcinogenesis What is carcinogen Examples of carcinogens Chemicals Physical Zoonoses Initiators and promoters . scielobraabc Chemical carcinogenesis PAULA A OLIVEIRA AURA COLA57543O RAQUEL CHAVES HENRIQUE GUEDESPINTO LUIS F DELACRUZ P and CARLOS LOPES Department of Veterinary Sciences CECAV University of Tr57569sosMontes and Alto Douro 5000801 Vila Real Por Initiation, Promotion and Progression. NST110, Toxicology. Department of Nutritional Sciences and Toxicology. University of California, Berkeley . Characteristics of . Cancer. Promotion. (reversible). ProportionPercentageChemicals tested in both rats and mice 350/59059%Naturally occurring chemicals 79/13957%Synthetic chemicals 271/45160%Chem. in Carcinogen. Potency Database 702/134852%Natural pesti Topics for Principles of Toxicology: Part B. Endocrine Toxicity. Carcinogenicity. Neurotoxicity. Persistence and Bioaccumulation. The topics for “Part C” (what we could not cover). Summary. The systemic problem. Activatedlymphocytesasametabolicmodelfor carcinogenesis AndrewNMacintyreandJeffreyCRathmell * Abstract Metabolicreprogrammingisakeyeventintumorigenesistosupportcellgrowth,andcancercellsfrequently beco welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best . possible. way.. OMICS Journals are poised in excellence by publishing high quality research. . Research Article Open Access Review Article Open Access Carcinogenesis & Mutagenesis “ ” Eleonora Giorgini 1 * , Gregorio Tugnoli 1 , Silvia Aprile 1 , Guido Collina 2 , Silvia Villani 1 , A Carcinogenesis. Are there differences in the mechanisms of carcinogenesis associated with chemical, radiation, or dietary carcinogens?. What is Carcinogenesis?. Carcinogenesis is the production of cancer cells or the process of normal cells transforming into cancerous cells. . A. Abdel . Baky. Associate Professor. Pharmacology and Toxicology. Carcinogenesis. Carcinogenesis is a multistep process at both the phenotypic and the genetic levels . that . end with the disease . Cell Growth. Neoplasms. Tumor Growth. Copyright © 2010, 2006, 2002 by Saunders, an imprint of Elsevier Inc.. Tumor Cell Division. Copyright © 2010, 2006, 2002 by Saunders, an imprint of Elsevier Inc.. Radiation effects:. Deterministic effects. Stochastic effects. Deterministic effects. A deterministic effects has a threshold in dose.. The severity of the effect is dose related.. Radiation induced cataracts are an example of a deterministic effects.. Carcinogenesis. Carcinogenesis or . Oncogenesis. =. creation of cancer= normal cells are transformed into cancer cells= characterized by . a progression of changes on cellular and genetic level . that ultimately reprogram a cell to undergo uncontrolled cell division, thus forming a malignant mass.. LEC.5. Chemical carcinogenesis:. General principles of chemical carcinogens;. I. . Could be . natural or synthetic chemical. ..  . II. . Chemicals either . direct acting chemical. (. active without transformation in the body). LEC.4. Carcinogenesis:. is a multistep process at both . phenotypic & genetic levels.. Phenotypic level . includes:. I. Excessive growth.. II. Local invasion.. III. Metastasis.. These three criteria are called collectively .