PPT-Carcinogenesis DR. AYSER HAMEED

LEC4 Carcinogenesis is a multistep process at both phenotypic amp genetic levels Phenotypic level includes I Excessive growth II Local invasion III Metastasis These three criteria are called collectively . Initiation, Promotion and Progression. NST110, Toxicology. Department of Nutritional Sciences and Toxicology. University of California, Berkeley . Characteristics of . Cancer. Promotion. (reversible). Name of Institute: Address: 74/D, Park road no - 3, Road no - 1 Ashok nagar, Ranchi , Jharkhand - 834002. Name of contact person: Mr. M.Hasan & Mr. Praveen Kumar Contact No. : 07677818297, 090318 Topics for Principles of Toxicology: Part B. Endocrine Toxicity. Carcinogenicity. Neurotoxicity. Persistence and Bioaccumulation. The topics for “Part C” (what we could not cover). Summary. The systemic problem. 1 CURRICULUM – VITAE Name : Father’s Name : Dr. Hameedul Hasan (Late) Date of Birth : May 23, 1955 Present Designation : Professor Department of Political Science, Aligarh Muslim Un Fact . vs. Fiction. Disclosures. No financial disclosures for myself or family. No off label uses will be discussed. One exception: I am a radiologist. 25+ years selling . xrays. for a living. Mortgages and college tuition still to pay. Dr. Fahd AL-MULLA. Phase II 2009. Lecture available http://www.al-mulla.org. Target knowledge . What is carcinogenesis. What is carcinogen. Examples of carcinogens. Chemicals. Physical. Zoonoses. . Initiators and promoters . NAMEDr G TAJUQUALIFICATIONMSc MPhil PhDDESIGNATIONASSISTANT PROFESSOROFFICICAL ADDRESSDEPARTMENT OF BIOCHEMISTRYC ABDUL HAKEEM COLLEGEMELVISHARAM 632 509VELLORE DISTRICTTAMIL NADUINDIARESIDENTIAL ADDR DroughtandfoodsecurityinthemiddleeastAnanalyticalframeworkMaysounHameedAliAhmadalipourHamidMoradkhaniCenterforComplexHydrosystemsResearchDepartmentofCivilConstructionandEnvironmentalEngineeringUnivers LEC.2. Most benign tumors grow slowly . & most of cancers grow faster . & eventually spread locally & to distant sites (metastasis) & causing death.. In some exception, some benign tumors grow more rapidly than some cancers e.g. leiomyoma (uterine fibroid), which is benign smooth muscle tumor influence by estrogen & so increase in size during pregnancy.. LEC.1. General Features . Inflammation is defined as "the response of living . vascularized. tissues to harmful agents.”. . It consists principally of vascular changes associated with leukocytes infiltration and systemic reactions. LEC.2. Binding of a particle to . phagocytic. leukocyte receptors initiates the process of active . phagocytosis. .. During engulfment, extensions of the cytoplasm (. pseudopods. ) flow around the particle to be engulfed, eventually resulting in complete enclosure of the particle within a . . eradication of . helicobacter pylori. and . beyound. WWW.MDPI.COM. Received: 17 . july. 2017. Accepted: 31 . july. 2017. Published: 3 Aug 2017. Presentation. by: Mohammad . panjalipour. Social medicine ward. LEC.3. Incidence of cancer. In male. . 30% Carcinoma of prostate. .. 14% Carcinoma of Lung.. 11% Carcinoma of colon & rectum.. In female. . . 31% breast carcinoma. .. 12% carcinoma of lung. . LEC.5. Chemical carcinogenesis:. General principles of chemical carcinogens;. I. . Could be . natural or synthetic chemical. ..  . II. . Chemicals either . direct acting chemical. (. active without transformation in the body).