PPT-Cardiovascular Outcomes Trials with Antihyperglycemic Agents

CVOTs 1 FDA CVOT Guidance2008 Timeline of Major Diabetes Outcomes Trials 2 Blue Intensive vs standard control using same set of glucoselowering agents Purple Intensive control with a specific agent vs standard care. Challenging Tradition. Chia-Chi (Josh) Lin, MD, PhD . 林家齊. Director of Phase I Center, Department of Oncology, National Taiwan University Hospital. Clinical Associate Professor, Graduate Institute of Oncology, National Taiwan University College of Medicine. 2. Center for Healthcare Studies, . 3. Center for Health Information Partnerships, . 4. Emergency Medicine, . 5. Preventive Medicine, . 6. Institute for Public Health and Medicine. Background. 117 million people in the US suffered from a chronic disease in 2012 . FDA-Mandated CV Safety Trials. 1. TECOS. (Trial Evaluating Cardiovascular Outcomes with Sitagliptin). Clinical Outcomes with Antihyperglycemic Agents. 2. Clinical Outcomes with Sitagliptin. Study Design. As of 10/2018. Aducanumab: amyloid antibody. Biogen. Albumin Immunoglobulin: treats primary immunodeficiency. G. rifols. Biologicals. ALZT-OP1: Mast cell stabilizer anti-inflammatory. AZTherapies. wabat@southern-med.com. PLATINUM DIVERSITY STUDY. National Co-PI. The first U.S. national study prospectively evaluating the clinical outcomes of 1,500 women and minorities undergoing coronary artery stenting. Enrollment completed. Fully funded by Industry. Focusing on Triglycerides. Primary and Secondary CVD Prevention Trials: . Evaluating Treatment of Triglycerides. Why Have Outcomes Trials of TG-Lowering Drugs Failed to Reach Primary Endpoints? . ASCEND . Evolocumab. in. Reducing Lipids and Cardiovascular . Events. Sabatine . MS. , . Giugliano RP. , . Wiviott . SD. ,. . e. t al. Kendrick Sparks, PGY3. September 17, 2015. Background. Reduction in LDL cholesterol has proven highly effective. Lindsay Mayet Lasseigne. LSU School of Medicine, Class of 2014. September 13, 2013. Objectives. Discuss the basics of MMC. Overview of the MOMS Trials. Overview of the Endoscopic Trials. Summarize controversies of fetal repair. UMMARY NFORMATIONPlan from largest small group product Health Maintenance OrganizationIssuer Name Kaiser Foundation Health Plan IncProduct Name Small Group HMO Plan Name Kaiser Foundation Health Plan UMMARY NFORMATIONPlan TypePlan from largest small group product Preferred Provider OrganizationIssuer Name Regence BlueShieldProduct Name Regence InnovaPlan Name Regence Blue Shield nongranfathered sm Antidiabetes. Medications:. Cardiovascular Benefits. Hengameh. . Abdi. Endocrine Research Center. Research Institute for Endocrine sciences. Shahid. . Beheshti. University of Medical Sciences. 13 December 2018. artbin. ). Ella Marley-Zagar, Ian . White. , . Mahesh . Parmar, Patrick Royston, . Abdel Babiker. e.marley-zagar@ucl.ac.uk. MRC Clinical Trials Unit at UCL. “London” Stata Conference. 9. . September . in Uganda. Prof. Kirsty Le . Doare. 14. th. March 2022. Preparation for maternal vaccine studies. Pregnancy is associated with complications (stillbirth, premature birth . etc. ) that must be differentiated from vaccine associated adverse events.. Darren K. McGuire, MD, . MHSc. Professor of Medicine. University of Texas Southwestern Medical Center. Conflict of Interest Disclosure. Clinical Trials Leadership. Takeda. Merck. Astra Zeneca. Janssen.