METHODS This is a retrospective crosssectional study based on weekly routine collection of hospital records of VLBW babies admitted to CMJAH in South Africa between 2013 and 2018 n 2333 Data was extracted from a standardized VLBW database administered by the unit which is used for registerin ID: 1046201
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1. BACKGROUNDNecrotizing Enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns. Hence, the aim of the study is to determine the factors associated with NEC among the very low birth weight (VLBW; weight<1,500g) infants in Charlotte Maxeke Johannesburg Academic hospital. METHODSThis is a retrospective cross-sectional study based on weekly routine collection of hospital records of VLBW babies admitted to CMJAH in South Africa between 2013 and 2018 (n = 2,333). Data was extracted from a standardized VLBW database administered by the unit which is used for registering all VLBW neonates who are born and/or admitted within the first 28 days (neonatal period) of life. Data analysis was done using statistical software for data management and analysis (STATA 15.0). A diagnosis of NEC was made based on clinical and radiological evidence of stage II or III, according to Bell’s criteria. Logistic regression analysis was performed to determine the significant risk factor associated with NEC.Factors Associated with Necrotizing Enterocolitis in a Public Hospital in Johannesburg, South Africa (2013 – 2018): A Cross Sectional StudyAjayi Oluseyi Mojisola1, Ballot Daynia2 and Chirwa Tobias11 School of Public Health, University of Witwatersrand, South Africa2 School of Clinical Medicine, University of Witwatersrand, South AfricaPRESENTED AT THE 23RD INTERNATIONAL AIDS CONFERENCE (AIDS 2020) | 6-10 JULY 2020RESULTSMajority of the sample population were males 53% and females 47%.Two hundred and forty-eight (10.63%) infants developed NEC. Multivariable logistic regression: the significant risk factors associated with NEC were, Oxygen given on day 28 (OR 1.27, 95% CI 1.052 – 1.531; p = 0.01), patent ductus arteriosus (PDA) (OR 1.61, 95% CI 1.153 – 2.244; p = 0.005), blood transfusion (OR 1.61, 95% CI 1.153 – 2.244; p = 0.005), surfactant therapy at initial admission (OR 1.49, 95% CI 1.146 – 1.945; p = 0.003) and delivery room nasal CPAP (OR 1.29, 95% CI 0.984 – 1.677; p = 0.06 (marginally significant). The Univariate logistic regression: maternal HIV (OR 1.54, 95% CI 1.214 – 1.959; p = <0.001)CONCLUSIONSPatent ductus arteriosus, oxygen given on day 28, blood transfusion, surfactant therapy and delivery room nasal CPAP were associated with increased risk of NEC in CMJAH VLBW infants. Mothers who were HIV positive were 54% more likely to have babies that will develop NEC.RESEARCH QUESTIONWhat are the factors associated with NEC among VLBW in a selected public health hospital?