PPT-Genome-wide association studies (GWASs) of Lung function and Smoking-behaviour related

Erzurumluoglu Liu and Jackson et al 2019 Metaanalysis of up to 622409 individuals identifies 40 novel smoking behaviour associated genetic loci Molecular Psychiatry Genetics of Smokers . Lesson 1 of 2. Write an essay to discuss the following statement. ‘Can we measure personality?’. Home learning. Is there a relationship between personality type and the sport people choose? . Why do some people prefer individual sports over team sports? . Presented by Karen . Xu. What you need to know. Basic genetic concepts behind GWAS. Genotyping technologies and common study designs . Statistical concepts for GWAS analysis. Replication, interpretation and follow-up of association results. Lecture 1: Introduction. Linkage studies. Traditional approach to identifying genes for human traits and diseases was through linkage.. For . Mendelian. diseases (e.g. Huntington’s disease) there is a clear co-segregation of genetic markers with disease within pedigrees.. -----. Module . 11 . – . Association Genetics. Nicholas Wheeler & David Harry – Oregon State University. What is association genetics?. Association genetics is the process of identifying alleles that are disproportionately represented among individuals with different phenotypes. It is a population-based survey used to identify relationships between genetic markers and phenotypic traits. BIOST 2055. 04/01/2015. Human Genome and Single Nucleotide Polymorphisms (SNPs). 23 chromosome pairs. 3 billion bases. A single nucleotide change between pairs of chromosomes. E.g. . Haplotype1. : AAGG. Nelson Freimer. UCLA Center for Neurobehavioral Genetics . What makes a genetic association significant?. Outline. The problem of achieving validated findings in psychiatric genetics. Approaches to genetic mapping and statistical significance. Boyang. . Li, Ke Xu. June 8. , 2018. VACS MVP Beta Project. Background. MVP smoking GWASs. Downstream analyses. - Genetic . correlation. - Heritability enrichment. Summary. Biostatistics | Yale School of Public Health. Bas E. Dutilh. March 4. th. 2013. Protein function. Phenotypic. . function. E.g. . apoptosis. GO: . Biological. . process. Cellular. . function. E.g. . ribosome. GO: . Cellular. component. Molecular. Dani. S. . Zander. , MD. Professor and Chair, Dept. of Pathology. Penn State College of Medicine/Penn State M.S. Hershey Medical Center, Hershey, PA. Smoking-Related Lung Diseases. Cause. Chronic obstructive lung disease (COPD): emphysema, chronic bronchitis, small airway disease. Genomics Lesson 12_1. Ross . Hardison. 4/19/15. 1. Genetic association. The occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.. Kesheng Wang, PhD. Department of Biostatistics and Epidemiology. College of Public Health. East Tennessee State University. 2. Outline. Introduction . Alcohol dependence (AD). Genetic study. . Subjects and Methods. from NHGRI’s . Planning . Workshop on the Future Opportunities . for . Genome Sequencing . & Beyond. Mark Gerstein & Rick Myers. Recommendations related to genome function. . Part 1: Workshop summary (Mark). 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Outline. General . overview of association . studies. Sample Results. Three steps to GWAS:. Primary scan. Replication. Fine mapping. Individual Site Score. North & West Galway City Enhanced Community Care . Overview . . Are Smoking and second hand smoke still a problem in Ireland?. What about e-cigarettes?. What’s the best way to stop smoking? . What can Quit Smoking West offer?.