PPT-Homology 3D modeling and effect of mutations

Miguel Andrade Faculty of Biology Johannes Gutenberg University Institute of Molecular Biology Mainz Germany a ndradeunimainzde Xray crystallography 103988 in PDB need crystals. Yusu. . Wang. Ohio State University. AMS Short Course 2014. Introduction. Much recent developments in computational topology. Both in theory and in their applications. E.g. , the theory of persistence homology. Peter K. álnai. Autumn school.  . Department . of Algebra. Ústupky. , . 24th – 27th November 2016. Algebraic topology. “Don’t be afraid of these ideas – you see them for the first time. When you see them for the tenth time, you won’t be afraid any more. They will have been safely stored on the list of things that you simply don’t understand.” . Presenter: Ronen . Talmon. Topological Methods in Electrical Engineering and Networks. January 19, 2011. January 19, 2011. Manifold Learning via Homology. 2. Sources. P. . Niyogi. , S. . Smale. , and S. Weinberger, . Benjamin J. . Liebeskind. Post-doctoral Fellow, UT Austin. PIs: Edward . Marcotte. , Rick Aldrich. How do we compare proteins across species?. Gravitropism defects. Waardenburg. syndrome. Significantly . What happens if there is a mistake (. mutation. ). in the DNA code?. Possibly proteins won’t be made or are made improperly.. If the mutations occur in the gametes, the offspring’s DNA will be affected positively, negatively, or neutrally.. and Interpreting Results. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. . Dun . dun. dun!!!!! . Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: . Mistake in replication or environmental effect that results in a c. Sept 4, 2013. Clustering Via Persistent Homology. Creating a simplicial complex. Step 0.) Start by adding 0-dimensional vertices . (0-simplices). Creating a simplicial complex. 1. .) . A. dding . 1. Given a mutation, identify its type. Predict how a mutation will affect a protein.. Mutations. Changes in genetic material (DNA). 2 main types of mutations. Point mutation- change in one or a few nucleotides (letters). The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. Comparative study of . morphological and anatomical structures. of animals and plants also indicate that they are constructed on the same basic plan and they shows certain similarities.. Such similarities are observed in:. Science. Learning intention. To understand the different types of mutations. . You will need. A pen and a piece of paper or a laptop to record your answers. . You may need the internet to search for answers. . mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. - results in a single changed protein.