PPT-Iron overload in thalassaemia

intermedia reassessment of iron chelation strategies Ali Taher1 Chaim Hershko2 and Maria Domenica Cappellini Thalassaemia intermedia TI is a syndrome marked by its diverse . thalassaemia. Professor John Porter. Red Cell Disorders Unit. University College London Hospitals and UCL . . j.porter@ucl.ac.uk. Professor John Porter. Red Cell Disorders Unit. University College London . haemoglobinopathies. Dr Farrukh Shah. Consultant haematologist. Joint Red cell disorders unit. Whittington hospital and UCLH. Why?. . . . . Erythron. . Macrophages. Hepatocytes. & other. IRON OVERLOAD. IRON. 10-15 mg/day in diet; 5-10% absorbed. Absorption increased in iron deficiency, pregnancy, erythroid hyperplasia, hypoxia. Heme iron absorbed best. Fe. 2 . much better than Fe. 3 . 1 Regular blood transfusions are needed to . maintainthe. . haemoglobin. over 10 g/. dL. at all times. . This usually requires 2-3 units every 4-6 weeks. Fresh blood. , filtered to . remove white . Anaemia. . ?. Anaemia . is defined as reduction in circulating.  . haemoglobin mass below. . the. critical. . level.. The normal . haemoglobin . (Hb) . is . 12-14. . gm%.. . WHO has . accepted . MD; FRCP (London); . FRCPEdin. ; . FRCSEdin. T. halassemia. Hemoglobin molecule. : is the iron-containing oxygen-transport . metalloprotein. in the red blood cells of all vertebrates.. The normal . haemoglobin. Kakavoulis. . Nikolaos. Patras Ioannis. What is . Thalassaemia. ?. . Thalassaemia. is a group of inherited disorders of hemoglobin synthesis characterized by . reduced . or . absen. ce. . of one . Donald Houston MD PhD FRCPC. Emily Rimmer MD MSc. FRCPC. May 1, 2020. Part 1: Iron Homeostasis, Iron Overload, and Laboratory Measures of Iron. Donald S. Houston MD PhD FRCPC. Presenter Disclosure. Speaker’s name: Donald S. Houston. . . Abeer. . Anwer. Ahmed. There is no physiological mechanism for eliminating excess iron from the body, so iron absorption is normally regulated to avoid accumulation. . Iron overload (. haemosiderosis. Consultant in Charge: Prof Mohd Khalid . . Presentation . by Dr Mohd . Monis . Department of . Radiodiagnosis. JNMCH, . Aligarh. Introduction. Basically. , iron is stored in the hepatic parenchyma and in the . مؤيد . علو. ش. Lec. . 2. Thalassaemias. Objectives:. 1-Define thalassemia and its main types(. β. and . α. ). 2- Know the . genetic . lesions of each of . β . and . α. thalassemia. 3-Know the difference between thalassemia minor and major.. T. halassaemia. , . Diagnosis . & . Management. Dr . Md. . Saqif. . Shahriar. MBBS ,MD(Cardiology). Interventional . cardiologist,NICVD,Dhaka. .. The cardiovascular complications . of . thalassaemia. . Assist. Prof. . Dr.Maysem. . Mouayad. . Alwash. . Note:. The . thalassaemias. are classified into . α. -, . β. -, . δβ. -, . γδβ. -, . δ. -, . γ. - and . εγδβ. -thalassaemias, according to the type of globin chain(s). of . haemoglobin. Ass. . Prof. . . Abeer. . Anwer. Ahmed. Normal adult blood contains three types of . haemoglobin. . Hb. . A . . Hb. . F . . Hb. . A2. Structure .