Mycobacterium tuberculosis The scientist who discovered M tuberculosis was A Louis Pasteur B Robert Koch C JeanAntoine Villemin D Calmette and Guerin Correct answer B MDR TB ID: 132009
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Slide1
Multiple choice questions
Mycobacterium tuberculosisSlide2
The scientist who discovered M. tuberculosis was:
A: Louis Pasteur
B: Robert Koch
C:
Jean-Antoine
Villemin
D:
Calmette
and Guerin
Correct answer: BSlide3
MDR TB:
is defined as resistance to
A: more than three anti tubercular drugs
B:
isoniazid
and
rifampin
irrespective of resistance to any other drug
C: INH, PZA and
Rifampicin
D:
fluoroquinolones
and at least one of the three
injectable
second-line drugs used to treat TB
Correct answer: BSlide4
XDR TB is defined as
A:
MDR TB that also is resistant to
fluoroquinolones
and at least one of the three
injectable
second-line drugs used to treat TB (
amikacin
,
kanamycin
, or
capreomycin
)
B:
resistant to two most effective first-line therapeutic drugs,
isoniazid
and
rifampin
irrespective of resistance to any other drug
C: MDR TB that is resistant to either one of the
injectable
second line drugs or second-line therapeutic
fluoroquinolones
D: Strain resistant to more than one drug (excluding co resistance to INH and
rif
)
Correct answer: ASlide5
Tuberculosis is transmitted through:
A: Infected water
B: Infected hands
C:
Infected blood
D: Infected air
Correct answer: DSlide6
Which of the following statements is incorrect:
A: People who are exposed to TB may or may not develop TB infection
B: People with TB infection may or may not develop TB disease
C: risk of developing TB disease is highest in first 2 years after infection
D: Every individual exposed to TB develops disease
Correct answer: DSlide7
Tubercular
Granulomas
are made up of:
A: organized aggregates of immune cells that surround foci of infected tissues
B: Damaged tissue cells and bacilli only
C: Fibrous and damaged tissue and bacilli only
D: Necrotic tissue and damaged tissue and bacilli only
Correct answer: ASlide8
Cord growth seen on
mycobacterial
culture is characteristic of:
A.
Avirulent
strains
B. Virulent strains
C. Saprophytic strains
D. Atypical
mycobacteria
Correct answer: BSlide9
Which one of the following are constituent of Lowenstein Jensen media except:
A.
Agarose
B.Malachite
gree
C. Mineral salts
D.
Asparagine
Correct answer: ASlide10
Following are the first line
antitubercular
drugs except:
A.
isoniazid
B.
rifampin
C. PAS
D. streptomycin
Correct answer: CSlide11
Which one of the following anti-tubercular drugs acts best in acidic pH:
A. INH
B.
Pyrazinamide
C. Streptomycin
D.
Rifampicin
Correct answer: BSlide12
Mutations in
katG
gene of
Mycobacterium tuberculosis
are responsible for resistance to:
A. INH
B.
Rifampicin
C.
Pyrazinamide
D. Streptomycin
Correct Answer: ASlide13
Which of the following tests are banned for diagnosis of tuberculosis:
A. Culture
B. ELISA
C. PCR
D. LPA
Correct result: BSlide14
Which of the following statements is incorrect:
A.
Mycobacteria
are obligate aerobes
B. Increased CO
2
tension enhances growth
C. Can not grow in cell free media
D. Doubling time of tubercle bacilli is about 18 hours.
Correct answer: CSlide15
One word answer
Identify the stain
ZN stain
Identify the organism
M. tuberculosis
Describe the morphology
Acid fast, Long slender, curved, bunch, beadedSlide16
True/ False
For people with TB infection and
no risk factors
, the risk is about 5% in the first two years
T
For people with TB infection and
no risk factors
, the risk is about 10% over a lifetime
T
For people with TB infection and
diabetes
, the risk is about 30% over a lifetime
T
For people with TB infection and
HIV infection
, the risk is about 7% to 10% over a lifetime
FSlide17
Which one of the following is a non cultivable
mycobacteria
:
A. M. tuberculosis
B. M.
Bovis
C. M.
leprae
D. M.
avium
intracellulare
Correct Answer: CSlide18
Which one of the following is a rapid grower
mycobacteria
:
A. M.
scrofulaceum
B. M.
kansasii
C. M.
fortuitum
D. M.
avium
intracellulare
Correct Answer: CSlide19
Buruli
ulcer is caused by:
A. M. tuberculosis
B. M.
ulcerance
C. M.
marinum
D. M.
chelonei
Correct answer: BSlide20
Swimming pool
granuloma
is caused by:
A. M. tuberculosis
B. M.
ulcerance
C. M.
marinum
D. M.
chelonei
Correct answer: cSlide21
Most common cause of disseminated opportunistic infection in AIDS patients in western world is:
A. M.
avium
intracellulare
complex
B.
Pneumocystis
carinii
C. Cryptosporidium
D.
Zygomycetes
Correct answer: ASlide22
Gerhard
Henrik
Armauer
Hansen,s
contribution to Microbiology was;
A. First identified
M.
leprae
as the cause of leprosy in 1873
B. First identified
M. tuberculosis
as a cause of TB in 1895
C. First identified
B.
anthracis
as a cause of Anthrax in 1872
D. First identified that small pox is a contagious disease
Correct Answer: ASlide23
Which of the following description suits
lepra
bacilli best:
A. acid-fast rod-shaped organism with parallel sides and rounded ends, mostly extracellular, often grouped together like bundles of cigars
B. acid-fast rod-shaped organism with parallel sides and rounded ends, chiefly in masses within the
lepra
cells (
globi
), often grouped together like bundles of cigars or arranged in a palisade
C. acid-fast rod-shaped organism with parallel sides and rounded ends, chiefly intracellular in Chinese letter form
D. acid-fast rod-shaped organism, extracellular, Chinese letter form
Correct answer: BSlide24
An adult male is presenting with hypo-pigmented patches on forearm, partial loss of
cutaneous
sensations in affected areas, presence of thickened
ulnar
nerve and presence of AFB in nasal smears. Your diagnosis is:
A.
Cutaneous
Tuberculosis
B. Leprosy
C. Atypical
mycobacteriosis
D.
Actinomycosis
Correct answer: BSlide25
A case of leprosy with good Cell mediated immunity usually presents as following form of disease:
A.
Lepromatous
B.
Tuberculoid
C. indeterminate
D. Borderline
Correct answer: BSlide26
Erythma
nodosum
leprosum
as seen in patients of leprosy on treatment, is due to:
A. Type I hypersensitivity reaction
B. Type II hypersensitivity reaction
C. Type III hypersensitivity reaction
D. Type IV hypersensitivity reaction
Correct answer: CSlide27
Presence of sulfur granules in pus is
pathognomonic
of:
A. Subcutaneous mycosis
B. Leprosy
C.
Actinomycosis
D.
Cutaneous
Tuberculosis
Correct Answer: CSlide28
There is a 30 year old male presenting with lumpy jaw,
suppurative
inflammation and formation of multiple abscesses and sinus tracts with discharge of pus containing sulfur granules. Most probable clinical diagnosis is;
A. Leprosy
B.
Actinomycosis
C. Subcutaneous mycosis
D.
Cutaneous
TB
Correct Answer: BSlide29
There is a 30 year old male presenting with lumpy jaw,
suppurative
inflammation and formation of multiple abscesses and sinus tracts with discharge of pus containing sulfur granules. Following types of
microscpic
examinations can be ordered to confirm the diagnosis, except;
A. Smear examination for Gram positive bacteria
B. Microscopic examination of Crush smear of granule
C. Smear examination for acid fast bacilli
D. KOH mount
Correct answer: DSlide30
There is a 30 year old male presenting with lumpy jaw,
suppurative
inflammation and formation of multiple abscesses and sinus tracts with discharge of pus containing sulfur granules. Best therapy in this case will be:
A.
Antitubercular
drugs
B.
Aminoglycosides
C. Penicillin
D. Co
trimoxazole
Correct Answer: C Slide31
Which one of them is non acid fast:
A. Mycobacterium tuberculosis
B.
Nocardia
C.
Actinomyces
D. Mycobacterium leprosy
Correct Answer: C