APOEapolipoprotein E CVDcardiovascular disease MTHFRmethylenetetrahydrofolate reductase 1 Santos et al Alzheimers Dement Amst 201776987 2 Lanctôt et al J Prev Alzheimers ID: 1037309
Download Presentation The PPT/PDF document "a Risk factors included body mass index..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. aRisk factors included body mass index ≥30, current smoking, hypertension, diabetes, and total cholesterol ≥200 mg/dlAPOE=apolipoprotein E; CVD=cardiovascular disease; MTHFR=methylenetetrahydrofolate reductase1. Santos et al. Alzheimers Dement (Amst) 2017;7:69–87; 2. Lanctôt et al. J Prev Alzheimers Dis 2023;1–11; 3. Pinho et al. Sci Rep 2021;11(1):16385; 4. Zupanic et al. J Alzheimers Dis 2021;81(3):1253–1261; 5. Gottesman et al. JAMA 2017;317(14):1443–1450Vascular disease, cardiovascular disease, and Alzheimer’s diseaseAlzheimer’s disease (AD) – ComorbiditiesSeveral cardiovascular conditions co-exist with AD; estimated prevalence is up to 74% for hypertension and up to 14% for stroke2Patients with AD may also be at an increased risk for CVDs, such as stroke,3 and subsequent increased risk of death4A 20-year study that tracked differences in brain amyloid deposition of individuals found that a cumulative number of vascular risk factorsa was associated with an increase in brain amyloid deposition5Shared risk factors for vascular diseases and dementia1Genetic risksMTHFR (methylenetetra-hydrofolate reductase)APOE gene(apolipoprotein E)Medical risk factorsHigh cholesterolHyper/hypotensionDiabetesLifestyle/behavioural/environmental risk factorsObesityExposure to air pollutionMajor depressive disorderSmokingLack of exercise and poor physical fitness