PPT-Hematopoietic Stem Cells (HSC)

Adapted from Gazit R Weissman IL and Rossi DJ 2008 HSC MPP Mouse Lineage low Sca1 cKit flk2 CD34 CD48 CD150 Human Lineage low CD90 CD45RA CD34. 57375e primer includes information about stem cells derived from embryonic and nonembryonic tissues Much of the information included here is about stem cells derived from human tissues but some studies of animalderived stem cells are also described wi f p ma y o t c n vo s ys m Rem ove the sk in fro m the re gion of the sku ll that extends betw een the ey es a nd ears and posterio rly to the back of the sku ll Scrap e aw ay m uscle and conn ective tissu e so you can see the su tures betw een t Caroline Cavanaugh, . nisha. . lipowcan. , Valerie . katulka. , will Watson, . Emily . bratlee. , . shayna. . svaranowic. , Maggie . mccall. Prior to this class, did you know that pulling stem cells from the umbilical cord was possible?. Embryonic stem cells are derived from eggs that have been fertilized . in vitro. .. They are donated for research purposes with informed consent of the donor.. The embryos from which human embryonic stem cells are derived are typically four and five days old and are hollow microscopic balls of cells called the blastocyst.. Transplantation . Apheresis and Mobilization . Donna . F. erguson, M.D.. July 16, 2015. History . Overview. Stem cell transplantation . HPC, Apheresis . HPC, Bone marrow . Autologous . Allogeneic . Donor and recipient . D. Craig Hooper, PhD, FNAI. Professor of Cancer Biology, SKCC, TJU. DouglasC.Hooper@Jefferson.edu. Therapeutic Modalities. Cancer immunotherapy. Hematologic disorders (non-malignant). Regenerative medicine. A stem cell is . a . “blank” cell. It can divide and produce identical . . copies – Self Renewal . P. rocess. Serves as a built-in repair system for . . . human . body. What Stem Cell does?. iPS. cells, self-renewal, differentiation, pluripotent, multipotent, Inner cell mass, Nuclear transfer (Therapeutic cloning), Feeder cells, LIF, embryoid body.. What are stem cells?. Cells that are able to renew themselves (. is. 1- . a . non-specialized. , . 2- generic . cell which can make exact copies of. itself . indefinitely and. 3- . can differentiate and produce specialized cells for the . various tissues . of the . 23. Learning Objectives—Level I. At the end of this unit of study, the student should be able to:. Define and differentiate the terms . neoplasm. and . malignant. and identify hematopoietic disorders that can be included in each category.. Lecturer . Dr. Samah A. Jassam BSc MSc PhD . MRSB. Al-Mustansiriya University . Collage of Pharmacy. Two . major types of stem cells in . mammals:. 1- . Embryonic . stem cells. , that are isolated from the inner cell mass of . Myeloid. Lymphoid. Histiocytic. Myeloid . neoplasms. (1) . Myeloproliferative. . neoplasms. (2) . Myelodysplastic. syndromes. (3) Acute myeloid leukemia. Features:. Recurrent genetic mutations. Increased bone marrow cellularity. Los Angeles ORT College\'s STEM Education Program stands out among STEM schools in California. The college provides a dynamic learning environment that encourages creativity, critical thinking, and problem-solving skills, ensuring that graduates are well-equipped for success. Def: the administration of hematopoietic stem cells from any source (ex: bone marrow, peripheral blood, umbilical cord blood) to reconstitute the bone marrow.. The Nobel Prize, 1990. E. Donnall Thomas .