PPT-Regenerative Medicine to Cure Sickle Cell Anemia

Robert A Brodsky MD Johns Hopkins Family Professor of Medicine and Oncology Director Division of Adult Hematology Glossary of terms BMT B one m arrow t ransplantation B lood or m arrow . EXAMINING PREVALENCE OF TOBACCO,. ALCOHOL, ILLICIT DRUG USE IN. ADULTS WITH SICKLE CELL ANEMIA. Catherine A. Seamon, Darlene T. Allen, . James G. Taylor VI, Jonathan Wilson, Gregory J. Kato . Disclosures. &. Intercollegiate Athletics. Sickle Cell Trait. (Hereditary Condition) . Red blood cells (RBC’s) are normally round, circular or disc shaped.. RBC’s have hemoglobin component (helps carry oxygen) and platelets (helps in clotting). BIOMEDICAL TECHNOLOGY 1. . . . . Regenerative medicine is growing replacement tissue or organs for patients who have sustained an injury or have had a disease that permanently damaged their tissue. . b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Jenny Pham. Protein Structure & Function. Spring 2015. Outline. Normal Adult Hemoglobin (. Hb. A). Function: Deoxygenated v. Oxygenated. Mutation in . Hb. A. Sickle Cell Hemoglobin (. Hb. S). Sickle Cell Anemia. was developed to create a greater awareness in . the Nashville . community of Sickle Cell Disease and to raise . funds for . patient care, . social services. , and research. . All . proceeds from the event . Katie Coltharp and Mariela Saenz. Names of Disorder. HbS. disease. Hemoglobin S disease. Hemoglobin SS disease. Sickling. disorder due to hemoglobin S. Sickle cell disease (broad term). Sickle cell disorders (broad group of conditions). CO binds to your . hemoglobin. , prevents oxygen from binding.  Can be fatal.   It is a "silent killer" as people often die in their sleep when a heater fails.. Carbon monoxide deaths are more likely to occur in winter. (SCAFO). By Pastor Marcia Taylor, Founder, CEO. 2021. Our programs are specifically designed and dedicated to accommodating the needs of those who are faced with the challenges of Sickle Cell such as access to care, socio-economical support services, mental health, substance abuse, family and/or care provider educational support, and isolation. . a sign . of an underlying . disorder. There are several kinds of anemia. . A. . physiologic . approach classifies anemia according to whether. the deficiency in erythrocytes is caused by a defect in . Wendy Blount, DVM. Practical Hematology. Anemia 101. Blood . Loss Anemia. Hemolysis. Non-Regenerative Anemias. Transfusion . Medicine. Polycythemia. Bone Marrow Disease. Coagulopathy. Central IV Lines. globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . Ass. Prof. . Abeer. . Anwer. Ahmed. Sickle cell . anaemia. Ass. Prof. . Abeer. . Anwer. Ahmed. Sickle cell disease is a group of . haemoglobin. disorders . resulting from . the inheritance of the sickle β‐. Anemia. True or absolute anemia is defined as a decrease in erythrocyte mass within the body. HCT, hemoglobin, and RBC count values are usually below their reference intervals.. Low erythrocyte parameters may also be present in blood when the total-body erythrocyte mass is normal (relative anemia). .