PPT-Cancer Genomics and Personalized

Infusion Therapies Aditya Bardia MD MPH Massachusetts General Hospital Dana FarberHarvard Cancer Center Harvard Medical School Boston MA No Disclosure No Relevant Disclosures To understand the principle of targeted therapies and importance of routine tumor genotyping in cancer . NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). Bioinformatics and Genomics. Applications:. Personalized cancer medicines. Disease determination . Pathway Analysis. Biomarker Discovery . An Interesting Point. “One . article estimated that the output from genomics may soon dwarf data heavyweights such as . What techniques are utilized to develop a personalized diagnosis for cancer patients. ?. . Can you envision such techniques occurring routinely for every patient in the foreseeable future?. Techniques. NGS analysis. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and . From Promise to Practice. PRECISION ONCOLOGY IS THE FUTURE OF CANCER CARE.. Tumor genome data informs cancer treatment and clinical pathways, resulting in better health outcomes.. New cancer therapies target the molecular pathways that lead to tumor genesis and progression.. Predictive, Preventive and Personalized Medicine & Molecular Diagnostics. Dr. Anton Yuryev. Nov 4, 2014. Curse of Dimensionality . of OMICs data:. We will never have enough patient samples to calculate robust signatures from large scale molecular profiling data. February 6, 2013. Howard K. . Koh. , MD, MPH. Assistant Secretary for Health . U.S. Department of Health and Human Services . Progress Review Overview. Summarize the burden of Cancer in the U.S. and the role of Genomics . Leming. Zhou, PhD. Assistant Professor. Department of Health Information Management . School of Health and Rehabilitation . Sciences. University of Pittsburgh. Human Genome Project. 1990 – 2003. Goals:. Views of genomics. [Solve challenges]. [Risks outweigh benefits]. Which of those applications of genomics do you approve of:. applications of genomics. % Approve/somewhat approve. Diagnose and plan treatments for cancer patients. Chromatic modifying genes. Supplementary Figure 1. . Oncoprint. depicting the genomic landscape of MIBC from the TCGA cohort with co-occurring alterations in canonical pathways and cellular functions. South West Genomic Laboratory Hub. 23. rd. February 2023. Haem germline findings. NGS testing for MPN. TATs. SNP arrays. WGS. 2. Haem Genomics update. A number of the genes included in haem NGS panels for their somatic actionability are also cancer susceptibility genes (CSGs) in the germline setting e.g. . Developed By Cancer . Information & Support Network. WWW.CISNcancer.org. CISN’s Mission:. To assist in the building of bridges between all of the organizations involved with cancer research.. Pharmacogenomics. Created by the School of Pharmacy Relations Committee for AMCP. Updated: . March 2022. Objectives. Define the various terms associated with pharmacogenomics & personalized medicine . Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .