PPT-22.4 Glycolysis: Oxidation of Glucose

Glucose in the bloodstream enters our cells where it undergoes degradation in a pathway called glycolysis Glucose obtained from the digestion of polysaccharides is degraded in glycolysis to pyruvate. C483 Spring 2013. 1. Which of these enzymatic reactions is NOT a control point for glycolysis?. . A. . Phosphoglycerate. kinase. . B. Hexokinase. . C. Phosphofructokinase. . D. Pyruvate kinase. In glycolysis, these enzymes are . Hexokinase. Phosphofructokinase. P. yruvate kinase. Phosphofructokinase is the key regulator of glycolysis in mammals. The enzyme is allosterically inhibited by ATP and allosterically stimulated by AMP.. Glycolysis . is the breakdown or catabolism of a six carbon glucose molecule in a series of enzyme catalyzed reactions to give 2 molecules of pyruvate which is a 3 carbon compound. Glycolysis takes place in all the cells in the cytosol . During the sequential reactions of glycolysis some of the free energy is stored in the form of ATP and NADH. . Metabolism. (Gluconeogenesis). Objectives. The . importance of . gluconeogenesis. as an important pathway for glucose production. The . main reactions of . gluconeogenesis. The . rate-limiting enzymes of . Chapter 16, . Stryer. Short Course. Glycolysis Expectations. Memorize/learn Figure . 16.1. Know overall reaction and stages. Explain . chemical/physiological purpose . of each . step. Learn structures. 1. How . many NADH are produced . . in . glycolysis per glucose?. (a) 1. (b) 2. (c) 4. (d) 8. 2. Which . one of the following molecules . in. . . glycolysis donates a phosphate group . to. . Part II. Dr. Kevin Ahern. Glycolysis. Summary. Glucose 2 ADP 2P. i. 2 NAD. . Yields. 2 Pyruvate 2 ATP 2 NADH 2 H. . 2 H. 2. O . Glycolysis. Fermentation in Yeast/Bacteria. Glucose. GA3P. Oxidative Phosphorylation. Figure 9.16. Electron shuttles. span membrane. MITOCHONDRION. 2 NADH. 2 NADH. 2 NADH. 6 NADH. 2 FADH. 2. 2 FADH. 2. or. . 2 ATP. . 2 ATP. . about 26 or 28 ATP. Glycolysis. M. . Asal. Bsc. . Pharmacy. MSC ,PhD Clinical . Biochemistry. GLYCOLYSIS. REACTIONS . OF GLYCOLYSIS . The conversion of glucose to pyruvate occurs in two stages . ,The . first five reactions of glycolysis correspond to an energy investment phase in which the phosphorylated forms of intermediates are . Mohammed Al-. Zubaidi. , . PhD. Laboratory Training. Introduction. The blood glucose level is the amount of glucose present in the blood. . The body naturally tightly regulates blood glucose levels as a part of metabolic homeostasis.. Carbohydrate Catabolism. • . glycolysis. : . glucose pyruvate acetyl CoA. • . TCA Cycle. :. acetyl CoA CO. 2. + NADH / FADH. 2. • . oxidative phosphorylation. Glycolysis & Gluconeogenesis. Glycolysis and Catabolism. Glycolysis is a sequence of enzyme-catalyzed reaction by which . glucose. is converted . into pyruvate. Pyruvate can be further aerobically oxidized. Glycolysis occurs in ten steps , and in two phases :-. The first 5 steps constitute the PREPARATORY PHASE in which the energy of 2 ATP is invested, raising the free-energy content of the intermediates and the carbon chains of all the metabolized hexoses are converted into a common product glyceraldehyde-3-phosphate. . Prepared by. Harpreet Malhotra. Florida State College at Jacksonville. 24.1 Introduction (1). In the catabolism of . carbohydrates. , . glycolysis. converts . glucose. . into . pyruvate. , which is then metabolized into .