PPT-Biochemical Aspects of Bile Acids and Salts

Clinical Biochemistry Unit Path Dept College of Medicine King Saud University Objectives Structure of primary bile acids and salts. Pancreatic lipase. , is secreted from the pancreas, that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to . monoglycerides. Acids/ BASES. Acids. When dissolved in water, it will . ionize . into positively charged hydronium ions (H. 3. O+) and negatively charged ions of some other element. . Bases. Also . known as an alkali. Bile Salts. Anson Lowe. October . 2, 2015. Medicine. METHODS IN ENZYMOLOGY, VOL. 400. Understand the physiologic function of bile salts. The determinants and regulation of bile salts synthesis. Enterohepatic. Cholestatic. Liability of Drugs. Mark S. Warren. 20. th. North American ISSX meeting | . Orlando. , FL | Oct . 20, . 2015. Drug-Induced Liver Injury (DILI). Common reason for failure of pharmaceuticals during drug development, common reason for removing approved medications from the market. Chemistry Section 3. Acids. Key terms. Electrolysis - Breaking down of compounds using electricity (d.c.). d.c – Direct current. Neutralisation – the reaction between an acid and an alkali to form a neutral solution.. The Good, the BAD and the Ugly . Dr Matthew Kurien. Academic Clinical Lecturer in Gastroenterology, University of Sheffield. Conflict of Interest: Good or BAD?. Ben, Age - 4. Sam, Age - 2. Chenodeoxycholic. Ramy Bishay. Department of Endocrinology. St Vincent’s Hospital, Sydney. Bile Acid Physiology. Produced exclusively in the liver as end-products of cholesterol catabolism. Facilitate . hepatobiliary. AP Chemistry, Mr. Guerrero. Acids. :. Sour taste. Turn litmus . red. Electrolytes- form ions in water. Corrosive-cause chemical burns to skin. React w/ metals to produce salt and H. 2. gas. . HX M . . Bile is a dark green to . yellowish brown . fluid produced by t. he. . hepatocytes. in the liver, draining through many bile ducts that penetrate the liver. . I. t is stored in the gallbladder and upon eating is discharged into the duodenum.. . . Clinical Biochemistry Unit, Path. Dept.. College of Medicine, King Saud University. . Objectives. Structure of primary bile acids and salts. Lipolysis and Micelles. Transport and chylomicron physiology. Daniel S. Kamin MD. Boston Children’s Hospital. Content Reviewers:.    . Sohail. Z. Husain, MD.    . Veronique . Morinville. MD, FRCP(C). Cholesterol metabolism. INTRODUCTION. Cholesterol . is the major sterol in the animal tissues.. Cholesterol . is present in tissues and in plasma either as free cholesterol or as a storage form, combined with a long-chain fatty acid as cholesteryl ester.. Cholesterol. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 17. Cholesterol in the body. The balance between cholesterol influx and efflux is not precise, resulting in a gradual deposition of cholesterol in the tissues, particularly in the endothelial linings of blood vessels.. Enterohepatic. Circulation. Prof. Mohammed . Alzoghaibi. zzoghaibi@gmail.com. 0506338400. Chapter : 64; pages: 783-786. Learning Objectives . Liver Digestive Functions. Physiologic Anatomy of Biliary Secretion.