PPT-Gene 210 Cancer Genomics

May 5 2015 Key events in investigating the cancer genome M R Stratton Science 201133115531558 Flow chart of the genome analysis for a cancer patient O Kilpivaara and L A Aaltonen. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. NGS analysis. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and . Alison J Whelan M.D., FACP. Professor of Medicine and Pediatrics. Director of the Hereditary Cancer Clinic. Washington University School of Medicine. Overview of today’s talk. Genetic testing. Genomic testing. Molecular Pathology Director: Frederick Nolte, Ph.D.. Cytogenetics and Molecular Genetics Director: . Daynna. Wolff, Ph.D.. Medical Director: Cynthia Schandl, M.D., Ph.D.. Associate Director: Julie Woolworth Hirschhorn, Ph.D.. 1. 2015 Precision Medicine Initiative: . Two Components: Cancer & National Cohort. “. An emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle”. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. February 6, 2013. Howard K. . Koh. , MD, MPH. Assistant Secretary for Health . U.S. Department of Health and Human Services . Progress Review Overview. Summarize the burden of Cancer in the U.S. and the role of Genomics . “. User facility. providing high-throughput DNA sequencing & analysis in support of DOE missions in alternative . energy. , . carbon cycling . & . bioremediation. .”. Opened in 1999. ~240 UC Employees. Web resource for exploring, visualizing, and analyzing . multidimentional. cancer genomics data. cBioPortal. : Purpose and Advantages. reduces. . molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. Outline : Functional genomicsIntroductionRelation between genotype and phenotypeEight model organismsE. coli; yeast; ArabidopsisC. elegansDrosophilazebrafish; mouse; humanFunctional genomics using re 20 18 , Vol. 9 http://www. jcancer .org 22 49 J J o o u u r r n n a a l l o o f f C C a a n n c c e e r r 201 8 ; 9 ( 1 3 ) : 2249 - 2 265 . doi: 10.7150/ jca . 24744 Review Gene Expression Detecti . Carl Pray. 1. Can advances in biology transform Asian agriculture? Challenges are large. Food production . Productivity growth . Crises – . Biological -Africa Swine Fever, corn stalk borer, fall armyworm, wheat rust. What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .