PPT-Precision Medicine and Evolving Indications for Hereditary Cancer Genetics

Robert A Somer MD Head Medical Oncology and Hematology Director Office of Clinical Research MD Anderson Cancer Center Cooper What is Cancer Official Definition A malignant proliferation of cells that is a result of a . From Promise to Practice. PRECISION ONCOLOGY IS THE FUTURE OF CANCER CARE.. Tumor genome data informs cancer treatment and clinical pathways, resulting in better health outcomes.. New cancer therapies target the molecular pathways that lead to tumor genesis and progression.. 1. 2015 Precision Medicine Initiative: . Two Components: Cancer & National Cohort. “. An emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle”. Jeremy Warner . MD, MS. Assistant Professor of Medicine and Biomedical . Informatics. Vanderbilt University. June 26, 2017. Three questions every cancer patient asks. Who’s like me?. How long have I got?. Prostate cancer is the most common cancer in males Most men develop prostate cancer by chance or as a result of risk factors that occur over the course ofa lifetime However approximately 10percentof m UterineCancerMost people develop uterine cancer by chance or as a result of risk factors that occur over the course of a lifetime However up to 10percentof people who are diagnosed with uterine cancer Page 1of 26UnitedHealthcare Commercial Medical PolicyEffective 01/01/2021Proprietary Information of UnitedHealthcare Copyright 2021United HealthCare Services IncUnitedHealthcareCommercial MedicalPolic ValueAwareness,Testing & Educate stakeholders on the value including physicians, pathologists, payers, patient Develop EU and UK-wide guidelines to promote the use of comprehensive testing at various Prostate cancer is the most common cancer in males . M ost men develop prostate cancer by chance or as a result of risk factors that occur over the course of a lifetime. However, approximately 10 pe Uterine Cancer Most people develop uterine cancer by chance or as a result of risk factors that occur over the course of a lifetime. However, up to 10 % ( percent ) of people who are diagnosed with CancerGenetics@utsouthwestern.edu | 214 - 645 - 2563 Somatic and Germline Genetic Testing Somatic Testing Most cancer is the result of acquired, or somatic , mutations that occur in a cell. Cancers July 201 MaeÕr ddogfen yma hefyd ar gael yn Gymraeg. This document is also available in Welsh. #$%&'!#%()$*+,-./!01232! 1 Genomics for Precision Medicine Strategy Executive Summary New genetic and g Karen L. Edwards, . PhD. Professor, Dept. of Epidemiology. School of Medicine. University of . California, Irvine. Irvine, CA. Outline. Two National Initiatives . Precision Medicine Initiative . Cancer . Biochemistry. qxsang@chem.fsu.edu. Biochemical, Molecular, and Pathological Mechanisms of Cancer, Stroke, Obesity, and Stem Cell Differentiation, and Cancer Biomarker and Drug Discovery for Precision . Owen Tan. 1. , Deborah Schofield. 1. , Rupendra Shrestha. 1. 1. GenIMPACT: Centre for Economic Impacts of Genomic Medicine, Macquarie Business School, Macquarie University, Australia.. Presenting at: .