Group Presentation Light Did you say Light The patch looks lovely bright Soon the white patch Grows and spreads The sun makes it A little red how can Vitiligo Harmless not even skin deep ID: 236093
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Slide1
A
Puneet
Group PresentationSlide2
Light! Did you say Light!
The patch looks lovely bright
Soon the white patchGrows and spreads
The sun makes itA little red,how can VitiligoHarmless, not even skin deepCan cause a trauma so deep?
Vitiligo - A social stigmaSlide3
VITILIGO
Chronic skin disease occurring worldwide in about 1% of the population, mostly between the age of 10-30
White spots occur when the skin no longer forms melanin (pigment that determines the color of your skin, hair, and eyes)
White patches of irregular shapes begin to appear on skinTotal absence of melanocytes microscopicallySlide4
CLINICAL FEATURES
Totally amelanotic
macule (patch) surrounded by normal skinVitiligo
macules characteristically have fairly discrete margins and they are round, oval or linear in shapeLesions enlarge centrifugally over time, but the rate may be slow or rapidVitiligo macule patches ranges from millimeter to centimeter in sizeSlide5
DISTRIBUTION PATTERN OF VITILIGO Slide6
Sub types of Vitiligo
Differ by anatomical location, and size of lesionsSlide7
Vitiligo cause- melanocyte destruction
Stress to the skin in form of wound, burn, excessive sun exposure or contact with bleaching phenol
Differential gene expression among
melanocytes
Inflammatory infiltrate of T cells & macrophages
4. Further induce
melanocyte
apoptosisSlide8
Why is the treatment important???
Vitiligo - not harmful medically, but emotional and psychological effects can be devastating.Affects self-esteem.
Women, are sometimes discriminated against in marriage. Developing vitiligo after marriage can be grounds for divorce.
People suffering from vitiligo feel embarrassed, depressed, or worried about other people’s reaction.Slide9
The primary goal of Vitiligo therapy is to repigment the affected skin. However, it is not always possible.
In such cases , depigmentation is the only available optionSlide10
Where de-pigmentation therapy requiredSlide11
List of depigmenting
agentSSlide12
COMPOSITION:-MONOBENZONE USP…..20% W/W CREAM BASE…………..Q.S.
When de-pigmentation is the only option...Slide13
MONOBENZONE
Monobenzyl ether of hydroquinone (MBEH)
Chemical Name: P- (Benzyloxy) - PhenolActs as a skin sensitizer
Topical application decreases the excretion of melanin from melanocytes in animalDepigmentation spreads to distant sites unexposed to MonobenzoneProgressive systemic reaction against melanocytesSlide14
Mechanism of action
INHIBITS
TyrosinaseSlide15
monobenzone is the most widely used
depigmenting agentSlide16
LIMITATIONS OF OTHER DEPIGMENTING AGENTSSlide17
Efficacy of monobenzone therapy
Residual patches of
vitiligo
affecting more than 70% of her skin surface
Depigmentation
after topical application of 20%
Monobenzone
daily
after
8 months
Pigment Cell Melanoma Res. 22; 42-65. REVIEW ARTICLE Update
on skin pigmentation therapies in
vitiligo
.
Rafael
Falabella
and Maria I.
Barona. Page No. 11Slide18
Administration:
Apply a thin layer of to the normal coloured skin area which requires depigmentation usually two to three times daily or as directed by physician. There is no recommended dose for children under 12 years of age except under the advice and supervision of a physician.
It may take up to 4 months before the full benefit of this drug takes effect. Once the desired skin colour is achieved, this medication is applied only as needed to maintain the new skin colour (usually 2 times a week).Use
cream regularly to get the most benefit from it. Inform the doctor if your condition persists or worsens after 4 months.Slide19
Side Effects of Monobenzone
Mild burning, Irritation, Redness,
Cracking, or Peeling of the treated skin may occur. If any of these effects persist or worsen, doctor needs to be informed.Slide20
precautions
This medication is for use on the skin only. cream should be applied with a patch test for 48 h to detect hypersensitivity.
Avoid application of to the eyelids and areas close to the eye.
Avoid getting this product in your eyes or on the inside of your nose or mouth. If the cream is accidentally applied in these areas, flush with plenty of water.After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight. Always use a sunscreen of SPF 15 or greater, and wear protective clothing when outdoors.Slide21
Albaquin treatment effects
As a depigmenting agent, Monobenzone
lightens up the pigmented areas and matches them with the white patches arisen out of Vitiligo skin disorder and can provide following effects to the patients : Permanently
depigmented skin Produce an even tone Match the skin around the vitiligo patches to a uniform light colourCreate a feeling of normalcy for the patientSlide22
Brings about permanent de pigmentation
Only drug used worldwide as a
depigmentation therapy for
vitiligoSafe and well toleratedNo toxicity to liver or kidney Permanently lightens skin
IDEAL THERAPY FOR UNIFYING SKIN COLOUR
Slide23
FOR
FURTHER
DETAILS
CONTACT
PUNEET
LABORATORIES PVT.LTD
.
605
Raheja
Plaza , B wing,
LBS Road,
Ghatkopar
(West),
Mumbai 400086, India.
TEL
.
91-22-61367000
Division Head :
Mrs.
Rashmi
Jain
Customer Care : 18002096261
E-MAIL :
customercare@puneetlabs.com
VISIT US AT: www.albaquin.com