PPT-Oxidative Inhibition of Erythrocyte Na

K Pump A Functionally Relevant Circulating Marker of Oxidative Stress Dr Chiachi Liu Molecular Cardiac Research Unit Sydney Medical School University of Sydney Australia Outline. +. -K. +. Pump: . A . Functionally Relevant Circulating Marker of Oxidative . Stress. Dr. Chia-chi Liu. Molecular Cardiac Research Unit . Sydney Medical School . University of Sydney. . Australia. Outline. to proteins in . Drosophila . melanogaster. Trevor Short. Dr. David Brown, Faculty Advisor. Previous research has suggested that there is a link between an accumulation of oxidative damage and aging [1, 2, 3, 4]. Oxidative damage occurs as a result of the inability of the body to detoxify reactive oxygen species that are generated in the body as a byproduct of cellular respiration; These reactive oxygen species may go on to react with proteins in the body and inhibit their ability to function normally [4, 5]. When a reactive oxygen species interacts with a protein, amino acid residues are converted to carbonyl groups [4,5]. This experiment was performed in fruit flies. & . Elimination. Dr. Sandro Percario. Editorial . Board Member. Professor. Ph.D., Federal University of . Para, Brazil. Guest Researcher. US Centers for Disease Control and Prevention, . USA. .. +. -K. +. Pump: . A . Functionally Relevant Circulating Marker of Oxidative . Stress. Dr. Chia-chi Liu. Molecular Cardiac Research Unit . Sydney Medical School . University of Sydney. . Australia. Outline. Oxidative Stress. O. 2. is readily reduced to form one of many Reactive Oxygen Species (ROS) . ROS cause cellular damage. DNA. Protein. Lipids. http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/ros.gif. Chapter 26, . Stryer. Short Course. Glucose Metabolism Overview. Gluconeogenesis. Glycogen . metabolism. Pentose Phosphate Pathway. Pentose Phosphate Pathway. Dual Purpose. Synthesis of “reducing potential”. Pratt and . Cornely. , Chapter 15. Goal: ATP Synthesis . Overview. Redox reactions. Electron transport chain. Proton gradient. ATP synthesis. Shuttles. Standard Reduction Potential. “potential to be reduced”. Clinical Chemistry Unit Pathology Department. College of Medicine, KSU. Objectives. By the end of the lecture, students are expected to:. Define a metabolic pathway.. Describe the general metabolic pathways for glucose (production and utilization). Kenneth Cintron, MD, FAAOS, ABoIM, MBA. Southeast Orthopedic Specialists. Jacksonville, . Florida, USA. 3. rd Annual Medical Conference . & . Community Outreach Program. . June . 10, 11 & 12, 2016. The structure of a noncompetitive inhibitor does not resemble the substrate and does not compete for the active site. .. Learning Goal . . Describe competitive and . noncompetitive inhibition . and reversible and irreversible inhibition. Anju. .M.P. BCH.10.05.12. One of the paradoxes of life on this planet is that the molecule that sustains aerobic life, oxygen, is not only fundamentally essential for energy metabolism and respiration, but it has been implicated in many diseases and degenerative conditions. Objectives: Oxidative Decarboxylation. By the end of this lecture, students are expected to:. Recognize the various fates of pyruvate. Define the conversion of pyruvate to acetyl CoA. Discuss the major regulatory mechanisms for PDH complex. Inhibition-. The decrease in enzyme activity/loss of activity. exert effect by decreasing . affinity of the enzyme for the substrate. decreasing the amount of active enzyme available for catalysis. by a combination of these effects. Anemia. True or absolute anemia is defined as a decrease in erythrocyte mass within the body. HCT, hemoglobin, and RBC count values are usually below their reference intervals.. Low erythrocyte parameters may also be present in blood when the total-body erythrocyte mass is normal (relative anemia). .