PPT-Hussein Al-Fazly Cholinomimetics, Cholinergic Antagonists and NMJ Blockers

1432020 1 Learning Objectives 1 Cholinomimetics Cholinomimetics explain how a directly acting and b indirectly acting cholinomimetic drugs produce their biological actions and state why the former are more selective in their actions. Muscarinic Agonists and Antagonists. Cholinergic Drugs. Agents that influence the activity of cholinergic receptors. Most mimic or block the actions of acetylcholine.. Cholinesterase inhibitors . Indirectly prevent the breakdown of acetylcholine. Introduction. Autonomic . nervous system (. ANS). A. utomatic. , self-governing, or . involuntary. No . conscious . control. Divided . into . sympathetic (alert system) and . parasympathetic nervous . Neuromuscular Blockers. Prevent acetylcholine from activating nicotinic. M. Cause muscle relaxation (paralysis). No oral forms. Cannot cross . Blood-brain barrier . No impact on CNS (paralysis, not sedation). Cholinergic Agonists Direct-Acting Cholinomimetics Direct-Acting Cholinergic Agonists (N & M) Cholinergic agonists (parasympathomimetics) mimic the effects of ACh on cholinoceptors. These agents broadly classified into Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist and Neurone blockers Dr. ISHOLA I.O. PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound, NA, AD, DA, ISOP 11/10/17 . Case 1: . 18 month old girl brought the ER by ambulance after grandmother was unable to wake her up from a long nap. . No concurrent illness. On exam: Shallow breathing, moans and withdraws in response to pain, does not open her eyes. Rest of physical exam is normal. . Cholinergic antagonist is a general term for agents that bind . to . cholinoceptors. (muscarinic . or nicotinic) and prevent the . effects . Abd. Al- Kader. PhD Pharmacology. THE CHOLINERGIC . NEURON. 1. The . preganglionic. fibers terminating in the . adrenal medulla. 2. The autonomic ganglia . (both parasympathetic and sympathetic. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. Cholinergic Transmission. that bind . to . cholinoceptors. (. muscarinic. . or nicotinic) . and prevent . the effects of . acetylcholine (. ACh. ) and . other . cholinergic agonists. The most clinically. useful of these agents are selective . . Dr.. Rashmi . Rekha. Kumari. Asstt. . Prof, . Deptt. . Of Pharmacology & Toxicology,BVC,Patna-14. Cholinergic transmission. Neurohumoral. transmission . either at synapse or neuroeffector junction in which acetylcholine act as a humoral agent(neurotransmitter) for transmission of action potential across the junction. Direct-Acting Cholinergic Agonists (N & M). Cholinergic agonists (parasympathomimetics) mimic the effects of ACh on cholinoceptors.. These agents broadly classified into. :. Endogenous choline esters, Ach. muscarinic. antagonist / . muscarinic. blocker.. OBJECTIVES. Classify & describe cholinergic antagonists. Explain actions, therapeutic uses & adverse reactions of cholinergic antagonists. Cholinergic antagonist / Cholinergic blockers. Written by Dr Amy Armstrong Nov 2023 . Emergency Medicine Teaching Programme. Clinical Case. A 45-year-old farmer is brought in as a standby to resus, having been found unwell in an agricultural store on his farm by another worker. .