PPT-SICKLE CELL ANEMIA in JOB CORPS

Gary Strokosch MD Jane Litvin MS Introduction History of sickle cell disease SCD Present in Africa for at least 5000 years 1910 Discovered in US Walter Clement Noel dental student from Grenada studying in Chicago . b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Jenny Pham. Protein Structure & Function. Spring 2015. Outline. Normal Adult Hemoglobin (. Hb. A). Function: Deoxygenated v. Oxygenated. Mutation in . Hb. A. Sickle Cell Hemoglobin (. Hb. S). Sickle Cell Anemia. Presenter: Bridget H. Wilson, Ph.D., MS, RN. Introduction. Sickle cell disease (SCD) pain continues to emerge among adolescents. Over 98,000 individuals are believed to have SCD within the United States. . Katie Coltharp and Mariela Saenz. Names of Disorder. HbS. disease. Hemoglobin S disease. Hemoglobin SS disease. Sickling. disorder due to hemoglobin S. Sickle cell disease (broad term). Sickle cell disorders (broad group of conditions). Sickle Cell Trait. (Hereditary Condition) . Red blood cells (RBC’s) are normally round, circular or disc shaped.. RBC’s have hemoglobin component (helps carry oxygen) and platelets (helps in clotting). What is the most common genetic disorder in the United States?. Background . Inheritance. Pathophysiology. Diagnostic . testing. Prognosis. Management of acute illness. Long-term management. Treatment options. Ali Al Khader, M.D.. Faculty of Medicine. Al-Balqa’ Applied University. Email: ali.alkhader@bau.edu.jo. Sickle Cell Anemia. The . most common familial hemolytic . anemia in . the . world. Sickle . cell . Dr. M. . Sofi. MD; FRCP (London); . FRCPEdin. ; . FRCSEdin. The term . sickle cell disease . (SCD) is generally used to describe all of the conditions associated with the phenomenon of . sickling. , whereas the term . a sign . of an underlying . disorder. There are several kinds of anemia. . A. . physiologic . approach classifies anemia according to whether. the deficiency in erythrocytes is caused by a defect in . . Sickle cell is a red blood disorder that can cause red blood cell to change form and cause lots of pain. Unfortunately this disorder can not be cured but can be stabled with the right treatments. In 1973 the average lifespan of a person with sickle cell was only 14 years. globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . Abeer. . Anwer. Ahmed. Sickle cell disease is a group of . haemoglobin. disorders . resulting from . the inheritance of the sickle β‐. globin. gene. . Sickle cell disease (SCD) is . an. . autosomal. Infection. Sherrill Brown, M.D.. Assistant Clinical Professor . Division of Infectious Diseases. UC Davis Medical Center. 9/8/18. Disclosures. None. Goals for Discussion. Discuss the mechanisms that make Sickle Cell patients more susceptible to infections.. Disease Education 5/17 Care of patients with sickle cell disease for primary care providers and emergency room personnel Table of Contents Chapter 1: Background About Sickle Cell Disease and Making t