The Intersection of Epidemiology Neurobiology and Clinical Practice with Veterans Katharine Bloeser LICSW Kelly McCoy PsyD VANTS Line To add in audio call the VANTS line below from your telephone Please be sure to mute your phone ID: 353356
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Slide1
Social Obstacles to Change
The Intersection of Epidemiology, Neurobiology, and Clinical Practice with Veterans
Katharine Bloeser, LICSW
Kelly McCoy, PsyDSlide2
VANTS Line
To add in audio, call the VANTS line below from your telephone. Please be sure to mute your phone.1-800-767-1750 Access Code:
71037Slide3
Social Determinants of Health
What are social determinants of health?
World Health Organization, August, 2008
“The social determinants of health are the conditions in which people are born, grow, live, work and age, including the health system.”Slide4
The
Biopsychosocial
Model
(1978)Slide5
The
Biopsychosocial
ModelSlide6
Do social or environmental factors influence
health
outcomes?Social Capital and Glucose Control
Black Veterans living in PhiladelphiaAfter controlling for individual factors (e.g., BMI, age), neighborhood poverty, and individual level mediators (e.g., medication adherence); those Veterans who reported that their neighborhood was a place where people worked together had a statistically significantly positive effect on HbA1c.
Long, J.A., et al. (2010)Slide7
Do social or environmental factors influence health outcomes?
Outcome
No. of respondents% Awarded benefits (95% CI)
% Denied benefits (95% CI)P-value
Employment2,25713.2%
(12.1-14.3)19.0% (17.3-20.6).11Income below poverty2,257
15.2% (14.5-15.9)
44.8% (43.2-46.3)<.001
Ever
homeless
3,077
12.0%
(11.6-12.4)
20.0%
(19.2-20.5)
.02
Deceased
3,077
10.4% (10.0-10.8)
9.7% (9.2-10.2)
.66
10 years later…
Demographic characteristic
Overall
PTSD
disability awarded
PTSD disability denied
P-value
Male sex
96.3%
96.3%
96.3%
>.99
Age, mean61.2(9.7)61.9 (9.5)59.3(9.8)<.001WhiteAfrican AmericanHispanic73.6%15.5%5.8%77.2%11.6%0.9%64.8%25.0%<0.1%<.001<.001<.001Married58.2%61.7%49.1%<.001
Murdoch, M., et al. (2011)Slide8
Do social or environmental factors influence health outcomes?
Employment status
Work hours
Government assistance
Mental health and wellbeing
National Poverty Center, April, 2011Veterans and DisabilitySlide9
Do social or environmental factors influence
mental health
outcomes?Neighborhood Violent Crime and Depression -Sample of current and former drug users
-270 block groups within Baltimore, MD from 1997-1998 -Violence is associated with psychological distress through perceptions of neighborhood disorder and personal experiences of violence.
Curry, A., Latkin, C., & Davey-Rothwell, M. (2008)Slide10
Do social or environmental factors influence mental health outcomes?
Why does neighborhood violence impact depression?
Fear of crime and violence less interaction among residents social isolation
“Mood congruent bias” Depression recall of more violence 3. Lack of financial means / Depression move towards less safe or more depressed areas
Curry, A.,
Latkin, C., & Davey-Rothwell, M. (2008)Slide11
Do social or environmental factors influence mental health outcomes?
Neighborhood socioeconomic status and individual perceptions of efficacy
-Bandura’s social cognitive theory defines self-efficacy, “people’s judgments of their capabilities to organize and execute a course of action required to attain designated types of performances.”
Bandura (1986)Slide12
Model 1: Neighborhood SES
Beta (p-value)
Model 2: Individual and Neighborhood SESBeta (p-value)Controls
Age.002 (.001).005 (.000)
Female-.056
(.010)-.020 (.353)Black-.066 (.125)
-.053 (.136)Neighborhood SES
% below poverty
-.008 (.000)
-.001 (.354)
Individual
SES
Income (log)
.132 (.000)
Assets
.073 (.028)
Missing assets
.111 (.047)
Education
.025
(.000)
Unemployed
-.133
(0.72)
Intercept
.080
-.900
R
2
.0277
.1047
Boardman, J.D. & Robert, S.A. (2000)Slide13
Do social or environmental factors influence mental health outcomes?
Maciejewski
, P.K.,
Prigerson
, H.G.,
Mazure, C.M. (2000)Slide14
Do social or environmental factors influence health outcomes?
Formation of individual self-efficacy:
Reflective self: How individuals feel they appear to others.
Comparative self: How individuals feel they compare with others.Observational self: How individuals view their behaviors.
Reflective self: “I
must be not worth much, because my neighborhood is in such chaos. No one seems to care.”
Comparative self: “Everyone around me is
just as depressed as I am, isn’t that normal?”
Observational self: “Its not like
I contribute anything to people, why try?Slide15
Social Influences on Health: Foundational Research
Suicide
(Durkheim, 1897)A deeply “psychological” and “private” act influenced by social integration and cohesion
Suicide patterns explained by social factsAnomic suicideAttachment Theory (Bowlby, 1940s-1980s)Importance of attachment bonds in early childhood to adult social development
Emotional development during childhood important to overall health
In Berkman, Glass, Brissette
& Seeman (2000) Slide16
Current Example:
Military Sexual Trauma
“Victims are often forced to choose between continuing military careers during which they are forced to have frequent contact with their perpetrators or sacrificing their career goals in order to protect themselves from future victimization.” – VA National Center for PTSD websiteSlide17
Adult Social Attachments
Numerous epidemiological findings link adult social attachments to health outcomes
E.g., adult attachment style associated with symptom perception and health care utilization (Ciechanowski
, Walker, Keaton, & Russo, 2002)While early childhood development is important, adult socialization also has large ramificationsE.g., employment opportunities, social upheaval, work stressSocial factors influence adult neurobiology, cardiovascular heath, and other biological systemsSlide18
What is “social support”?
Berkman
, Glass, Brissette & Seeman (2000) Slide19
What is “social support”?
Social and cultural context
Network structureQuantity and structure of relationshipsQuality of relationships Types of support
Emotional: love, caring, sympathy, esteem, intimacyInstrumental: material needsAppraisal: assistance with decision makingInformational: provision of advice or information Slide20
What is “stress”?
Stress is perceived by the brain
Responses to stress can be adaptive or maladaptiveBrain initiates behavioral and physiological responses to stressThe stress response involves communication between brain, cardiovascular, immune, autonomic, and endocrine systemsSlide21
Figure 1.
Non-linear network of mediators of allostasis involved in the stress response. Arrows indicate that each system regulates the others in a reciprocal manner, creating a non-linear network. Moreover, there are multiple pathways for regulation – e.g. inflammatory cytokine production is negatively regulated via anti-inflammatory cytokines, as well as via parasympathetic and glucocorticoid
pathways, whereas sympathetic activity increases inflammatory cytokine production. Parasympathetic activity, in turn, contains sympathetic activity. Reprinted from McEwen 2006 by permission.
McEwen (2009)
Environmental factors
e.g., Access to healthy foods Exposure to war, death,
and destruction Social isolation Exposure to toxins Child abuse Insufficient finances
Unsafe living conditions Occupational stressSlide22
Effects of Social Environment on Personal Health
Neurobiology
Structural remodelingCardiovascular health
Metabolic changesImmune functionThe immune-brain loopLife expectancyTelomere lengthSlide23
What about “good” stress?
Eustress
versus distress
Common examples of eustress: Meaningful community participation, overcoming a challenge, physical exercise, competing in a tournament, advocacy work
Eustress
DistressPositive perception of stressors (“a challenge”)Negative perception of stressors (“a threat”)
Fosters meaning and hope
Fosters aggression and withdrawalPromotes hardiness and effective
coping
Promotes anxiety and depressionSlide24
Social and Psychological Interventions Help
Changes in brain structure in response to stress can be reversed
Behavioral and social factors promote resilience
Evidence of changed brain functioning in response to psychotherapyEvidence of increased telomerase activity following lifestyle change in men with prostate cancer (Ornish et al., 2008)Social and behavioral interventions “reduce the chronic stress burden and benefit brain and body health and resilience”
(McEwen, 2009)Slide25
Effects of Illness and Injury on Social Cognition
Specific illnesses and injuries are associated with restricted social support
Some illnesses and injuries are also associated with difficulty processing social informatione.g., traumatic brain injury,
frontotemporal dementia, autism, schizophreniaIn both cases, rehabilitation includes development of enhanced social supportSlide26
The
Biopsychosocial
Model
(1978)Slide27
Person Level Interventions
Awareness of effects of social hierarchy in clinical encountersPrevent experiences of rejection
Promote experiences of caring and esteemAwareness of importance of social interactions on healthProvide emotional, instrumental, appraisal, and informational supportAssess past and present social experiences and their influence on current health and health behaviorsPatient-centered care approaches that emphasize Veteran empowerment and patient-provider relationshipSlide28
Local Community Interventions
Facilitate development of health-promoting social networks for Veterans Prevent provider burnout through healthy relationships at work
Appreciate the importance of social influences on behavior change Provide green space in the local settingProvide access to resources and education for VeteransConnect the dots between health care and social servicesPromote Veteran empowerment and involvement in decision makingStudy and address health care and other benefit inequitiesSlide29
Larger Community Interventions
Advocate for political decisions that promote healthy communities Advocate for political decisions that promote income and health care equalityLook for and address institutional discrimination
Promote adequate access to healthy foods and health education for people of all income levelsPromote cultural norms that reflect values of respect for all people, physical exercise, stress reduction, work-life balance, and holistic health care Slide30
Using Social Determinants of Health to Guide Interventions: Some examples
Informing policy,Mental Health Impact Assessment (MHIA)
Englewood, Chicago, IllinoisSlide31
Neurobiology and Policy
“Finally, it should be noted that the social and physical environments in which we live are, at least in part, the products of practices and policies of private enterprise and government and these can be changed by changing those policies. Indeed, virtually all of the policies of government and business have powerful effects on health. Indeed, they have a top down effect via the brain on all the physiological systems involved in stress and adaptation (McEwen, 2007). Therefore, monitoring how the brain is affected by such policies is another important future direction of
neuroimaging
research because animal models can only give clues, but the study of the adaptability of the human brain is the ultimate goal!” (McEwen, 2009)Slide32
Harlem Children’s Zone
“By addressing the needs of the entire community, Harlem Children’s Zone isn't simply helping children beat the odds, it's helping to change the odds.” Slide33
Veterans’ Horticulture InitiativeSlide34
Resurrection After Rape
(Atkinson, 2010)Interventions combine cognitive processing therapy with a social justice approach“Rape is a social problem, not individual pathology”
Appropriately acknowledges the roles of politics and culture in sexual trauma and recoveryE.g., addresses unhealthy social norms including those that blame the victim, addresses rape as a men’s issues as much as it is a women’s issue, community engagement Slide35
Veteran Webinar
“Life Through the Eyes of Wounded Warriors”Veteran presentation as part of Patient Care Services Grand RoundsMutual benefit to Veterans (self-efficacy) and VA
employees (informs policy)Slide36
Veteran-Driven ResearchSlide37
Question for the Audience
Are there any initiatives you have undertaken that illustrate the principles of social determinants of health?Slide38
Resources
World Health Organization (WHO) Commission on Social Determinants of Health http://www.who.int/social_determinants/en/
VA Center for Health Equity Research and Promotionhttp://www.cherp.research.va.gov/ HHS National Partnership for Action to End Health Disparitieshttp://minorityhealth.hhs.gov/npa/Slide39
References
Atkinson, M. (2010). Resurrection after Rape: A guide to transforming from victim to survivor. Oklahoma City, OK: Resurrection After Rape Publishing
Bandura, A. (1986). Social Foundations of Thought and Action. Englewood Cliffs, NJ: Prentice-Hall.Berkman, L. F., Glass, T., Brissette, I., &
Seeman, T. E. (2000). From social integration to health: Durkheim in the new millennium, 51(6): 843-857.Boardman, J. D., & Robert, S. A. (2000). Neighborhood socioeconomic status and perceptions of self efficacy. Sociological Perspectives, 43(1): 117-136.
Ciechanowski, P. S., Walker, E. A., Katon, W. J., & Russo, J. E. (2002). Attachment theory: A model for health care utilization and somatization
. Psychosomatic Medicine, 64: 660-667Curry, A., Latkin, C., & Davey-Rothwell, M. (2008). Pathways to depression: The impact of neighborhood violent crime on inner-city residents in Baltimore, Maryland, USA. Soc Sci
Med, 67(1)L 23-30.Slide40
References (cont.)
Long, J. A., Field, S., Armstrong, K., Chang, V. W., & Metlay, J. P. (2010). Social capital and glucose control. Journal of Community Health,
35(5): 519-526.Maciejewski, P. K., Prigerson, H. G., & Mazure, C. M. (2000). Self-efficacy as a mediator between stressful life events and depressive symptoms: Differences based on history of prior depression.
British Journal of Psychiatry, 176: 373-378.McEwen, B.S. (2009). The brain is the central organ of stress and adaptation. Neuroimage, 47(3): 911-913.Murdoch, M., Sayer
, N. A., Spoont, M. R., Rosenheck, R., Noorbaloochi, S., Griffin, J. M.,
Arbisi, P. A., & Hagel, E. M. (2011). Long-term outcomes of disability benefits in US veterans with posttraumatic stress disorder. Arch Gen Psychiatry, 68(10): 1072-1080.Ornish, D., Lin, J., Daubenmier, J., Weidner, G.,
Epel, E., Kemp, C., Magbanua, M. J., Marlin, R., Yglecias, L., Carroll, P. R., & Blackburn, E. H. (2008). Increased telomerase activity and comprehensive
lifestlye changes: A pilot study. Lancet Oncology, 9: 1048-1057.