TGF signalling Notch signalling TGF signalling Receptor Serinethreonine kinase Activationrepression of gene expression SMAD transcription factors and regulators RanGTP importins and exportins ID: 352395
Download Presentation The PPT/PDF document "Tyrosine kinase signalling (review)" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Tyrosine kinase signalling (review)
TGF signalling
Notch signallingSlide2
TGF signalling
Receptor Serine/threonine kinase
Activation/repression of gene expression
SMAD transcription factors and regulators
RanGTP
,
importins
and
exportinsSlide3Slide4Slide5Slide6Slide7Slide8
Flores, A. N.
et al.
(2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer
Nat. Rev. Urol.
doi:10.1038/nrurol.2014.195Slide9
Flores, A. N.
et al.
(2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer
Nat. Rev. Urol.
doi:10.1038/nrurol.2014.195Slide10Slide11Slide12Slide13Slide14Slide15Slide16
Numb expression in human mammary tumors.
Pece
S et al. JCB 2004;167:215-221
© 2004 Rockefeller University PressSlide17
Loss of Numb expression in tumors is due to enhanced ubiquitination and proteasomal degradation.
Pece S et al. JCB 2004;167:215-221
© 2004 Rockefeller University PressSlide18
Re-expression of Numb selectively suppresses growth in Numb-negative tumors.
Pece S et al. JCB 2004;167:215-221
© 2004 Rockefeller University PressSlide19
Increased Notch signaling in Numb-negative tumors.
Pece S et al. JCB 2004;167:215-221
© 2004 Rockefeller University PressSlide20
Effects of perturbation of Numb or Notch activity in mammary tumor primary cells.
Pece S et al. JCB 2004;167:215-221
© 2004 Rockefeller University PressSlide21