PPT-Tyrosine kinase signalling (review)

Author : pamella-moone | Published Date : 2016-06-07

TGF signalling Notch signalling TGF signalling Receptor Serinethreonine kinase Activationrepression of gene expression SMAD transcription factors and regulators

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Tyrosine kinase signalling (review): Transcript

TGF signalling Notch signalling TGF signalling Receptor Serinethreonine kinase Activationrepression of gene expression SMAD transcription factors and regulators RanGTP importins and exportins. Kinase. Inhibitors. Charles Harrell. Outline of Material Presented. Definition of Cancer. Understanding . Kinases. Kinase. Inhibitor Functionality. Economic Considerations. Assigned Reading. Homework Questions. BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. G Protein Coupled Receptor Pathways. G Protein Coupled Receptors. Seven membrane-spanning domain receptors. requirements, protocols . and . test specifications. ITU-T. STUDY GROUP 11. Kaoru . Kenyoshi. . (. NEC, Japan). Vice-chairman, SG11. on . behalf of . Wei . FENG . (. Huawei, China). Chairman, . SG11. RTK’s--How do they work?. EGFR signaling and . ras. MAP k. inase cascades. PI3K, PKB, . PLC. g. PTPs (Protein Tyrosine Phosphatases). Epidermal growth factor. Neurotrophic growth factor (NGF) isolated from mouse. Kinections. Map P36507. MEK2/MAP2K2. P36507. -T230. -S216. +S226. +S222. B-. Raf. P15056. COT/MAP3K8. P41279. PDK1/PDPK1. O15530. MORG1. Q9BRX9. SGK1. O00141. BMAL1. O00327. T484. KRT8. P05787. S74. k. inase . i. nhibition. Danny Rayes . Epidermal Growth Factor Receptor. EGF + EGFR .  growth and proliferation. Mutant EGFR (no ligand) .  growth and proliferation. Inhibiting activating mutations. k. inase . i. nhibition. Danny Rayes . Lung Cancer and Epidermal Growth Factor Receptor. Lung cancer is a leading cause cancer-related death . Two types of lung cancer. Non small cell (NSCLC) 80-85%. Kinections. Map P52564. PKR/EIF2AK2. P19525. DCTN1. Q14203. MKK6/MAP2K6. P52564. -Y219. +T211. +S207. MEKK1/MAP3K1. Q13233. COT/MAP3K8. P41279. ASK1/MAP3K5. Q99683. MEKK2/MAP3K2. Q9Y2U5. MEKK3/MAP3K3. . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. BIOCHEMISTRY. Basic Characteristics Of Cell Signaling . Cell must respond appropriately to external stimuli to survive.. Cells respond to stimuli via cell signaling. Each cell is programmed to respond to specific combinations of extracellular signal molecules. BIOCHEMISTRY. Basic Characteristics Of Cell Signaling . Cell must respond appropriately to external stimuli to survive.. Cells respond to stimuli via cell signaling. Each cell is programmed to respond to specific combinations of extracellular signal molecules. MadeinGermanyGNALLING DEVICESNIMU Non-Invasive Monitoring Unit is a reusable monitoring system which informs the operator as soon as the rupture disc responds to an overpressure or vacuum situation T Overview. 1. 2. Autocrine. AKA: . Juxtacrine. 3. Endocrine. 4. Paracrine, Autocrine. Nervous. Juxtacrine. 5. Same signal .  Many different effects. Different Receptors. Different Intracellular Events. Protein . kinase. A . protein . kinase. is a . kinase. enzyme that modifies other proteins by chemically adding phosphate groups to them (. phosphorylation. ). . Phosphorylation. usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. .

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