PPT-Joint Linkage and Linkage Disequilibrium Mapping

Key Reference Li Q and R L Wu 2009 A multilocus model for constructing a linkage disequilibrium map in human populations Statistical Applications in Genetics and Molecular Biology 8 1 Article 18. As every instructor of population genetics knows the term is a barrier not an aid to understanding LD means simply a nonrandom association of alleles at two or more loci and detecting LD does not ensure either linkage or a lack of equilibrium The te HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. Key Reference. Li, Q., and R. L. Wu, 2009 A . multilocus. model for constructing a linkage disequilibrium map in human populations. . Statistical Applications in Genetics and Molecular Biology . 8 (1): Article 18.. Trey Ideker. Genetics 101:. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. A) Alleles at different loci are independent. B) Alleles at different loci are physically close to each other and on the same chromosome. C) Alternate alleles at the same locus are not independent. D) Alleles at different loci are not independent. HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction. Inheritance of genes that are on different chromosomes vs. close together on the same chromosome. When genes are closely linked on the same chromosome, how does this affect their segregation pattern?. Jan. 6 . - . 10, 2020. Shanghai. Two faces of one process: phylogenetics vs. population genetics. Phylogenetics – model of speciation. Tine et al., 2014. Population genetics – model of coalescence. Genes in populations. Gene and genotype frequencies. Hardy-Weinberg . equilibrium. Linkage . disequilibrium. Descriptive statistics for quantitative traits. Genetic variance. Heritability. Relationships among relatives. PBG 430. Linkage. Linkage is the non-random . association. of two or more phenotypes or sequences in a population (genes/sequences are (almost) always inherited together). Biological explanation for linkage: genes or sequences are closely located in the same chromosome. 1.38 pairs of homosexual brothers that demonstrated possible maternal inheritance.Pedigree and linkage analysis to locate possible loci on the X chromosome responsible for inheritance ofhomosexuality. 1 Genetic and Physical MappingThe ultimate goal of mapping is to identify the gene(s) responsible for a given phenotype or the mutation responsible for a specific variant.The initial steps in mapping cation of marker-trait associations, mapping Quantitative Trait Loci (QTL), candidate gene identi cation, basis for high-resolution genetic ne-mapping, which provide powerful tools for genetic anal Linkage disequilibrium (LD). Definition of linkage disequilibrium. Importance of disequilibrium . Measures of disequilibrium. SNP selection. Public resources. Tag SNP selection programs. Imputation. Definitions.