PPT-Computational methods for genomics-guided immunotherapy

Sahar Al Seesi and Ion M ă ndoiu Computer Science amp Engineering Department University of Connecticut Class I endogenous antigen presentation Somatic rearrangement of Tcell receptor genes. . SciEnce. through Computational Thinking (DISSECT). Enrico Pontelli. What is NSF?. DISSECT – grant from the National Science Foundation. An independent . federal agency . created . by Congress in 1950 . NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). Allen Lee. Center for Behavior, Institutions, and the . Environment. https://. cbie.asu.edu. Computational Social Science. Wicked collective action problems. Innovation -> Problems -> . Innovation. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. The Future of Cancer Care. Brad . Loncar. Biotech . commentator . and . investor for 8+ . years.. Manager of a biotech-focused family office.. Franklin Templeton Investments and U.S. Department of the Treasury.. Jim . Demmel. EECS & Math Departments. www.cs.berkeley.edu/~demmel. 20 Jan 2009. 4 Big Events. Establishment of a new graduate program in Computational Science and Engineering (CSE). “. Multicore. Stephanie Breda, David Czosniak, Tara Regmi, and Shaon Parial. PHM142 Fall . 2018. Instructor: . Ms. Maya Latif. Coordinator: Dr. J. Henderson. Immunotherapy. The . immune system. is crucial in the defence and protection against pathogens we may come across day to day. Any infection or disease that compromises our immune system puts us at risk of illness or death. . selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. Tandy Warnow. Departments of Bioengineering and Computer Science. http://. tandy.cs.illinois.edu. Course Details. Office hours: . To be determined. Course webpage: . http://tandy.cs.illinois.edu/598-. Associate Professor Philip Beale. Chair ANZGOG Clinical Trials Group. Medical Oncologist Sydney. Concord Hospital. Chris O’Brien Lifehouse. Royal Prince Alfred Hospital. Outline. Background to immunotherapy. Associate Professor Philip Beale. Chair ANZGOG Clinical Trials Group. Medical Oncologist Sydney. Concord Hospital. Chris O’Brien Lifehouse. Royal Prince Alfred Hospital. Outline. Background to immunotherapy. Chemical Exchange Saturation Transfer (CEST) MRI . Sanhita Sinharay. (joining BSSE as an Assistant Professor in early 2021). https://faculty.mdanderson.org/profiles/sanhita_sinharay.html. Aggressive tumors are acidic. Bionano Genomics, San Diego, California, United States of America. Abstract. Pat Lynch, PhD. Background. Generating high-quality finished genomes replete with accurate identification of structural variation and high completion (minimal gaps) remains challenging using short read sequencing technologies alone. The .