PPT-Hemoglobin

Electrophoresis Electrophoresis Electrophoresis is a means of separating hemoglobins It depends on the migration of the hemoglobin molecules dissolved in a buffer on or in a supporting medium when an electric current is passed through them. Blood transports materials through out the body inside blood vessels.. Plasma. Straw colored, nonliving part of blood.. 90% Water. Helps to regulate body temperature. Contains Electrolytes. Plasma transports blood cells, products of digestion and hormones throughout the body.. b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Jenny Pham. Protein Structure & Function. Spring 2015. Outline. Normal Adult Hemoglobin (. Hb. A). Function: Deoxygenated v. Oxygenated. Mutation in . Hb. A. Sickle Cell Hemoglobin (. Hb. S). Sickle Cell Anemia. Hemoglobin. Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs.. Hemoglobin. Hemoglobin (. Human respiratory system. Dr. . Jagdish. . Kaur. P.G.G.C.,Sector. 11. Chandigarh. Haldane . effect. Describes . the effect of oxygen on CO. 2. transport. . Deoxygenated . blood can carry increasing amounts of carbon . Hemolysis. is defined as the premature destruction of red blood cells (RBCs).. Anemia results when the rate of destruction exceeds the capacity of the marrow to produce RBCs. Normal RBC survival time is 110. H2500 Hemoglobin Bovine Lyophilized powder H3760 Hemoglobin Bovine Dried erythrocytes Methemoglobin and oxyhemoglobin content is not determined H2625 Hemoglobin Bovine Substrate powder Prepar Hemoglobin variant trait is common and can occur in any race or ethnicity You may have heard of sickle cell trait before while not exactly the same sickle cell trait and hemoglobin variant trait are s Adult male: 4.6 – 6 million. Adult female: 4.2 – 5 million. Red blood cells are: . Tiny, flexible biconcave discs. Lacks a nucleus. Can bend when going through tiny capillaries. RBC’s are constantly manufactured. Learning Objectives. ▪ . Different . Hemoglobin . variants. ▪ . Characteristics of . Hemoglobin . variants and . Hb. ▪. Different . Hemoglobin . combinations. Hemoglobin . V. ariants. There . must be . OBJECTIVES. Describe the . structure . of hemoglobin molecule. Describe . synthesis . of hemoglobin in brief.. List the . functions. of hemoglobin.. Enlist . various types. of normal and abnormal hemoglobin’s.. . By – . Dr. Sunita Mittal. Learning Objectives. ▪. Iron metabolism . ▪. Hemoglobin catabolism (Fate of old RBCs) . ▪. Prehepatic. Jaundice. Iron . (Fe. +2. ) Metabolism. Iron is essential for . Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs.. Hemoglobin. Hemoglobin (. Hemoglobin. . Found in the RBC.. Responsible for carrying oxygen to all cells in the body.. Also binds to carbon dioxide and carries it to the lungs from the cells to be released.. Buffer against change in [H.