Joshi et

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2016-11-17 45K 45 0 0

Joshi et - Description

al., 2013. Glutamate Activity in . ACC. Statistical Significance. : . **. p. ≤. 0.01. Spectroscopy in. . Adolescent Males with . HF. -Autistic Disorder. Higher glutamate in this area of the brain is hypothesized to be associated with ASD. . ID: 489750 Download Presentation

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Joshi et




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Slide1

Joshi et al., 2013

Glutamate Activity in

ACC

Statistical Significance

:

**

p

≤0.01

Spectroscopy in Adolescent Males with HF-Autistic Disorder

Higher glutamate in this area of the brain is hypothesized to be associated with ASD.

Slide2

Clinical Trials

Registration @ ClinicalTrials.govRegistration Number: NCT01333865URL: http://www.clinicaltrials.gov/ct2/show/NCT01333865

Study Approved by: Partners Human Research Committee Institutional Review Board

Study Funded by: the Norma Fine Pediatric Psychopharmacology Fellowship Fund & the Pediatric Psychopharmacology Council Fund

12-week Open-label Trial of Anti-Glutamate Agent Memantine Hydrochloride (Namenda) for the Treatment ofSocial Impairment in Young Adults withHigh-functioning Autism Spectrum Disorder

Clinical and Research Program in Pediatric Psychopharmacology

Slide3

ASD

Features: Mean Response

Informant-Rated: Social Responsiveness Scale (SRS)

Clinical and Research Program in Pediatric Psychopharmacology

SRS

:Mean Raw ScoreBaseline: 99 ±17Endpoint:71 ±18Reduction:28 ±25Effect Size:1.57

Statistical Significance: *p≤0.05, **p≤0.01, ***p≤0.001

***

Take away: Caretakers rated patients to have improvements in social skills and behavior after trial of Namenda.

Slide4

Total Mean Response

***

Mean Response by Domain

ASD

-RS

Mean TotalBaseline: 31 ±7.4Endpoint:21 ±8.3Reduction:10 ±7Effect Size:1.30

Clinical and Research Program in Pediatric Psychopharmacology

Clinician-Rated: ASD Rating Scale

ASD

Features: Mean Response

Statistical Significance

:

*

p≤

0.05,

**

p

≤0.01,

*

**

p

≤0.001

Slide5

Non-verbal Communication Performance

Clinical and Research Program in Pediatric Psychopharmacology

Reading Non-Verbal Emotional Cues:

DANVA2

Performance

Total Errors

Statistical Significance

:

*

p≤

0.05,

**p≤0.01, ***p≤0.001

Take Away: After medication, patients show increase in

abiity

to recognize emotions conveyed through facial expressions

Slide6

Adverse Events

Clinical and Research Program in Pediatric Psychopharmacology

Reported > I visit

Experienced any AEs:

6 (33.3%)

Serious AEs:

None

Treatment Limiting AEs

:

N=1Decreased energy,emotional numbness,feeling dissociated,feeling on edge(resolved on d/c)

Take away: Patients reported very few adverse side effects while on Namenda

Slide7

Reimer, Fried,

Biederman

et al., 2013

Impaired driving ability associated with autism

The MIT

AgeLab

Driving Simulator

Characterizing Driving

Behavior

in

Young Adults with ASD

Difficulties attending to the roadway: - Higher vertical gaze position - Wider dispersion of horizontal gaze scanning - Focus more on the median Drive at higher level of arousal: - Increased level of anxiety

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