PPT-Joint profiling of chromatin accessibility, DNA methylation and transcription in single

Stephen Clark Reik Lab Babraham Institute Background Bulk analyses mask intercellular differences vs Background Bulk analyses mask intercellular differences Silva J Smith A . Exploring transcription factor binding and the . epigenomic. landscape. Saurabh. Sinha. (several slides here are courtesy of . Lisa . Stubbs). Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. of epigenetics. A. dult. . stem cells know their . fate. !. For example: m. yoblasts. . can . form . muscle . cells. only.. Hematopoetic. . cells only become blood . cells. .. .....b. ut. . all . Genomics. 2015/16. Silvia del Burgo. Introduction. Same genome for all cells that arise from single fertilized egg, Identity? .  . Epigenomic. signatures . Epigenomics: study of chemical changes in DNA and histones (without altering DNA sequence) that are inheritable and involved in regulating gene expression, development, tissue differentiation and suppression of TE. . Geeta. . Narlikar. ) . . January 19, 2017 – Transcription Initiation and its Regulation in Bacteria. January 23, 2017 – Transcription Initiation and its Regulation in Eukaryotes. January 26, 2016 – Chromatin 1. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. Geeta. . Narlikar. ) . . January 19, 2017 – Transcription Initiation and its Regulation in Bacteria. January 23, 2017 – Transcription Initiation and its Regulation in Eukaryotes. January 26, 2016 – Chromatin 1. and Its . Regulation (Carol A. Gross; . Geeta. . Narlikar. ) . . Biochemistry 201 – Biological Regulatory Mechanisms. January. 19, 2016 – The Transcription . C. ycle. January . 21, 2016 – Regulation of Transcription in Prokaryotes. . 1. The . trp. Operon. Contains 5 genes coding for proteins (enzymes) required for the synthesis of the amino acid tryptophan. Also contains a promoter and operator.. When tryptophan levels in the cell are low, the expression of the . Epigenetics. and gene regulation. Andrew P . Read. Centre for Genomic Medicine. St Mary’s Hospital, Manchester. http://www.galtoninstitute.org.uk/wp-content/uploads/2018/10/BN180916_Genetics-in-Medicine-4-1.pdf-web-1.pdf. Chromatin-binding factorshistone macromolecules that bind either directly or indirectly to DNA.Transcription factorhistone protein that directly binds to DNA.Architectural proteinsProteins that have a ZOO LOGY Cell Biology Cell Regulatory Mechanisms : Chromatin Remodeling 1 Development Team Paper Coordinat or: Prof. Kuldeep K. Sharma Department of Zoology, University of Jammu Principal Investigat . WS 2019/20 - lecture 15. 1. Bioinformatics III. Epigenetics. . refers. . to. . alternate. . phenotypic. . states. . that. . are. . not . based. on . differences. in . genotype. .. They. .