PPT-Epigenetics : DNA methylation

I Requirements for epigenetic materials Need to be transmitted faithfully during mitosis and meiosis possibly along with DNA gt cell need to have maintenance mechanisms similar to semiconservative mechanism of DNA replication. Kevin Ferriter. Mariah Minder. From Yesterday…. Do you think your brain cell and your blood cell have the same DNA sequence?. Genetics. Every cell contains all of your DNA. Not every cell expresses all of your DNA. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. :. DNA . methylation. I. Requirements for epigenetic materials. Need to be . transmitted faithfully . during mitosis and meiosis (possibly along with DNA). -> . cell need to have . maintenance mechanisms similar to semi-conservative mechanism of DNA replication. CpG. Island landscape. Héctor. Corrada Bravo. CMSC702 . Spring . 2013. (many slides courtesy of Rafael Irizarry). Genetics: the alphabet of life. Letters of DNA sequence carry the . information. How is this information read and parsed.. Daniel Messinger. , Ph.D.. Messinger. Hmmm…. ‘Mothers . who were . pregnant during a 1944 famine in the . Netherlands. were . more likely to have children—and grandchildren—prone to heart disease, diabetes, and obesity. . CpG. Island . landscape (part 2). Héctor. Corrada Bravo. CMSC858P Spring 2012. (many slides courtesy of Rafael Irizarry). How do we measure DNA methylation?. Microarray Data. One question…. Where do we measure? . Joo. ’ Kim. Louisiana State University. What is . Epigenetics. ?. “the study of mitotically and/or . meiotically. heritable changes in gene function that can not be explained . by changes . in DNA sequences” – (Riggs et al. 1996). -. MGMT, ABCB1 and ABCG2 methylation in glioma. Moritz C. Oberstadt, PhD. Tumor diseases. High maligne tumors with low 5 years overall survival (OS):. - Brain tumors . (13%/15%). - Stomach- . (12%/13%). . Bioinformatics . SPRING 2019. BIO307. Jasmin Šutković. 2. 9th May 2019. . Outline . Introduction . Micro RNA s. Epigenetic. DNA Methylation . In silico study – Bioinformatics . Examples . Epigenetic  refers to heritable changes in gene expression (active versus inactive genes), that does not involve changes to the underlying DNA sequence; a change in . One twin is large . at birth and has an. enlarged tongue and hypoglycemia. . The other twin appears normal.. . What could. be causing . these profound clinical differences between 2 infants who are. Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution . Richard P. . Ebstein. , Ph.D.. Department of Psychology. National University of Singapore. & Hebrew University, Jerusalem. UNDER REVIEW. Psychosocial stress. Psychosocial stress along with the coping styles that people employ when challenged by stress, are considered important determinants of overall wellbeing . ‘Epi’: On top of. . Definition:. The . study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.. DNA. How many cell types are in the human body?. Claire Olson. Steven Roberts. University of Washington. School of Aquatic and Fishery Sciences. PCSGA. Vancouver, WA. September 2014. Outline. Background: epigenetics and DNA methylation. Results: characterizing DNA methylation and examining degree of heritability.