PPT-Epigenetics : DNA methylation

I Requirements for epigenetic materials Need to be transmitted faithfully during mitosis and meiosis possibly along with DNA gt cell need to have maintenance mechanisms similar to semiconservative mechanism of DNA replication. Part II. DNA Regulatory . Elements. BNFO 602/691. Biological Sequence Analysis. Mark Reimers, VIPBG. Epigenetic Marks . (as per current use). Any stable modification of DNA or chromatin. DNA modifications. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. Nasonia . vitripennis. Steffan. Llewellyn, The Centre for Interdisciplinary Science. Dr.. . Eran. . Tauber. , Department of Genetics. ABSTRACT. The . presence of 5-hydroxymethylcytosine (5hmC) within the mammalian ‘. :. DNA . methylation. I. Requirements for epigenetic materials. Need to be . transmitted faithfully . during mitosis and meiosis (possibly along with DNA). -> . cell need to have . maintenance mechanisms similar to semi-conservative mechanism of DNA replication. CpG. Island landscape. Héctor. Corrada Bravo. CMSC702 . Spring . 2013. (many slides courtesy of Rafael Irizarry). Genetics: the alphabet of life. Letters of DNA sequence carry the . information. How is this information read and parsed.. Daniel Messinger. , Ph.D.. Messinger. Hmmm…. ‘Mothers . who were . pregnant during a 1944 famine in the . Netherlands. were . more likely to have children—and grandchildren—prone to heart disease, diabetes, and obesity. . CpG. Island . landscape (part 2). Héctor. Corrada Bravo. CMSC858P Spring 2012. (many slides courtesy of Rafael Irizarry). How do we measure DNA methylation?. Microarray Data. One question…. Where do we measure? . Nadia Khan, Rick Smith, . and Anna . Kuperman. Epigenetics 2012. Introduction. Most Genome Wide Approaches were adapted from technologies originally developed for detecting methylation at the level of a single gene. -. MGMT, ABCB1 and ABCG2 methylation in glioma. Moritz C. Oberstadt, PhD. Tumor diseases. High maligne tumors with low 5 years overall survival (OS):. - Brain tumors . (13%/15%). - Stomach- . (12%/13%). Stephen Clark – . Reik. Lab, . Babraham. Institute. Background. Bulk analyses mask intercellular differences . vs.. Background. Bulk analyses mask intercellular differences . Silva . J, Smith . A, . λ. -. DNA . . Objective: To represent de novo methylation of DNA. Model. for epigenetic changes in DNA. Methylase. DNA. Cytosin. Me. Internship. . epigenetic. Methyltransferases transfer a methyl group to the DNA. By: Michelle Rivera, . eSmirna. . cantu. , Alexa Campos. What are pesticides?. Pesticides is a generic term that many chemicals fall under. . Brief functions of pesticides. . List of pesticides used. . Specificity and Universal Cancer Detection using Plasma. James G. Herman, M.D.. Jeff Wang, Ph.D.. The UPMC Hillman Cancer Center. The University of Pittsburgh. The Johns Hopkins University. Highly Prevalent Tumor Specific Methylation Defined for Lung CA. Claire Olson. Steven Roberts. University of Washington. School of Aquatic and Fishery Sciences. PCSGA. Vancouver, WA. September 2014. Outline. Background: epigenetics and DNA methylation. Results: characterizing DNA methylation and examining degree of heritability.