PPT-V15: Analysis of DNA methylation data

WS 201920 lecture 15 1 Bioinformatics III Epigenetics refers to alternate phenotypic states that are not based on differences in genotype They . glucoregulatory. genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Authors: Frederic . Guenard. , Yves . Deshales. , Katherine . Cianflone. , John G. . Kral. , Picard Marceau, and Marie-Claude . Nasonia . vitripennis. Steffan. Llewellyn, The Centre for Interdisciplinary Science. Dr.. . Eran. . Tauber. , Department of Genetics. ABSTRACT. The . presence of 5-hydroxymethylcytosine (5hmC) within the mammalian ‘. Detection Methods. Daniel . Goan. Anna Tseng. Joanna . Tychowski. Feb 2, 2012. MSP. Overview. DNA Digestion Based. COBRA. Real-time MSP. MethyLight. Bisulfite Sequencing. Pyrosequencing. MassARRAY. Southern-blot hybridization. Fade Gong & Nam Nguyen. Introduction. DNA . methylation. in mammals occurs at . CpG. sites, where it serves many functions:. Self vs. non-self identification (such as in viral/bacterial infection). . . Global and . G. enome-Wide Studies. . . Yanbin Dong MD PhD. . Regents’ . Professor, Pediatrics. Georgia Prevention Institute. Department of Pediatrics. Medical College of Georgia. Nadia Khan, Rick Smith, . and Anna . Kuperman. Epigenetics 2012. Introduction. Most Genome Wide Approaches were adapted from technologies originally developed for detecting methylation at the level of a single gene. DNA Methylation & Cadmium Exposure. in utero. An Epigenetic Analysis Activity for Students. . This teacher slide set was created by Dana Haine, MS, of the UNC-Chapel Hill Superfund Research Program, which is funded by the National Institute of Environmental Health Sciences (P42ES005948).. Stephen Clark – . Reik. Lab, . Babraham. Institute. Background. Bulk analyses mask intercellular differences . vs.. Background. Bulk analyses mask intercellular differences . Silva . J, Smith . A, . Jeffrey S. Morris. Del and Dennis McCarthy Distinguished Professor. Department of Biostatistics. The University of Texas M.D. Anderson Cancer Center. Big Data in Biomedical Research. Explosion of complex information-rich data has revolutionized biomedical research. BS222 – Genome Science Lecture 7. Module structure. Genomes, sequencing projects and genomic databases (VT. ). Sequencing . technologies (VT. ). What is a gene? . (VT. ). Epigenetics overview (PVW. λ. -. DNA . . Objective: To represent de novo methylation of DNA. Model. for epigenetic changes in DNA. Methylase. DNA. Cytosin. Me. Internship. . epigenetic. Methyltransferases transfer a methyl group to the DNA. 110 Report Figure 1: Methylenetetrahydrofolate reductase role in generegulation and methionine- homocysteine metabolism Gynecology Obstetrics & Reproductive Medicine 2016;22(2): A 38 year-old pregna I. Requirements for epigenetic materials. Need to be . transmitted faithfully . during mitosis and meiosis (possibly along with DNA). -> . cell need to have . maintenance mechanisms similar to semi-conservative mechanism of DNA replication. ​. Elizabeth Riffel. Biomedical Sciences. PROPOSED . SOLUTION. With respect to adopting the techniques practiced within this study to sufficiently predict PPD, more studies will have to be conducted to confirm this is a reliable technique. Though this study provides much headway on a prevalent issue impacting women and families in the United States..