PPT-5. Acid-base reactions 5.8: Effects of enzyme microenvironment on acidity and basicity

Hydrophobic active site Most biochemical reactions occur in enzyme active sites not in bulk solution The active site microenvironment is often very different from water Σ 1478 kJ mol. Chemical Reactions. Chemical reactions are the heart of chemistry. Chemical reactions involve a change from reactant substances to product substances. The products have physical and chemical properties different from those of the reactants.. Definitions . Strong Acids. HCl. HBr. HI. HNO. 3. HClO. 4. H. 2. SO. 4. Acid: a species that supplies H. +. ions to water. Strong acid: an acid that completely ionizes in water forming an H. +. ion and an anion. Ali Al-Mawlawi. What Is Stomach Acidity?. Stomach acidity is when you’re stomach produces to much acid (gastric). Acid has benefits but sometimes it crosses the line. . What It Does (damage)?. Stomach acidity causes you to have pain in the stomach and sometimes it causes diarrhea. . Lecturer Dr. . Kamal. E. M. . Elkahlout. Assistant Prof. of . Biotechnology. 1. CHAPTER 4. Recent Advances. 2. Enzymatic reactions in biphasic liquid systems. E. nzyme catalyzed . reactions could be performed in solvents other than . Acid-Base chemistry & pH. Recognizing acid/base and conjugate base/acid. Calculation of pH, . pOH. , [H. 3. O. +. ], [OH. -. ]. Calculating pH for solutions of strong acids/base. Ionization constant: . Daley & . Daley. Chapter 5. :. Acid-base theory. 5.1 Acids & bases: overview & basics. 5.2 Acid & base strength. 5.3 Equilibrium acid-base reactions. 5.4 The leveling effect of solvents. 11-. 1. Activity: Precipitation Reactions. When a solution of lead(II) nitrate is mixed with a solution of potassium chromate, a yellow precipitate forms according to the equation:. Pb(NO. 3. ). 2. (. Katja. Dove. PhD Candidate, . Department of Biochemistry, University of Washington. Email: Katja.Dove@seattlecolleges.edu. Please turn in your take-home part for midterm 1 BEFORE class. I will hand back in-class exams at the end of class today. Pharmaceutical Medicinal Chemistry-I. Dr. Bilal Al-Jaidi. Assistant Professor in Medicinal Chemistry and Drug Design. Faculty of Pharmacy, Philadelphia University-Jordan. Email: bjaidi@philadelphia.edu.jo. 5.18.12. Go over pg. 74-75 and concept review . Lecture: Indicators and pH . (A) pg. 76-77. Universal Indicator. Bases. Acids. Phenolpthalein. Indicator. Identifies if a base is present: turns. . pink. Enzyme activation energy and reaction co-ordination, . acidbase. , covalent, metal . ion, . Proximity and orientation . effects, . Preferential transitional state . binding . Reaction Rates and the. Strong Acids. HCl. HBr. HI. HNO. 3. HClO. 4. H. 2. SO. 4. Acid: a species that supplies H. +. ions to water. Strong acid: an acid that completely ionizes in water forming an H. +. ion and an anion. These are the OPPOSITE of neutralization reactions (i.e. acid-base reactions). Rather than forming a salt and water from an A-B reaction, a salt and water react to form an acid and a base.. You MUST determine if you have a Strong or Weak Acid and a Strong or Weak Base.. Topics:. 3A_Chemical Reactions and . Stoichiometry. 3B_Types of Chemical Reactions. 3C_Driving Forces, Energy Changes and Electrochemistry. Topic 3A_Chemical Reactions and . Stoichiometry. Chemical Equations.