PPT-1 Innate immunity Abul K.

Abbas University of California San Francisco FOCiS Lecture outline Components of innate immunity Recognition of microbes and dead cells Toll Like Receptors NOD Like Receptors Inflammasome. Chapter 22. Functions of the Immune System. Destroy pathogens (organisms that cause disease). Detect and kill abnormal cells such as cancerous cells. Remove dead cells and debris from the body. Pathogens. Evolutionary View. Epithelial barriers to infection. Four main types of innate recognition . molecules:TLRs. , CLRs, NLRs, RLRs. NF-. . B, the master transcriptional regulator of inflammation . Inflammation and recruitment of phagocytes. Present before exposure to pathogens. Present at birth. Non-antigen specific. Consists of:. Skin… barrier for microbes and viruses. Compromised by abrasion or laceration. Sebacious. sweat is acidic (pH 3-5)… prevents colonization of bacteria. A. The body has two main mechanisms of defenses. 1. Innate defense mechanisms – first line of defense. A) These defenses are non-specific and . inherited. Immunity Overview. B) Examples:. 1. ) Physical barriers. E . Wolf decoy for geese (plenty in New England).. Why are these decoys efficient?. Geese do not have pictures to teach their young ones what animals to avoid…. … and so they must be born with images of predators engraved in their brain. All organisms have innate behaviors that are inherited from parents that develop independently from the environment. Innate behavior is inherited from an individual’s parents and is not modified by the individual and is generally not affected by the organism’s environment, including an organism’s experiences.. In short, it is safe to state that immunity refers to the rules and principles that govern diplomatic relations between states and other entities with legal personality within the international system.. Cells of the Immune System. Physical & Chemical Barriers. Innate and Adaptive Immunity. Innate Defenses. Nonspecific physical and chemical barriers that contribute to resistance against infection.  . Immunity . is defined as the capacity of the body to resist the pathogenic agents. It is the ability of the body to resist the entry of . different types of . foreign bodies like bacteria, . virus, . The term Immunity has traditionally referred to the resistance exhibited by the host towards injury caused by microorganism and their product.. However, protection against infectious disease is only one of many consequences of immune response, which in its entirety is concerned with the reaction of the body against any foreign antigen.. Assis.Prof.Dr. . Suhad Faisal . Hatem. Innate immunity. . is considering first line of defense, an immediate response to a pathogen that does not confer lifelong protective immunity. It is includes :. Dr. . Bipin. Patel. introduction. INTRODUCTION. The term “immunity” is referred to the . resistance of an individual . towards . injury. caused by . microbial stimuli . (microorganisms & their products) & . Features of adaptive immunity:. Adaptive immunity is characterized by the following:. 1. Antigenic specificity: (. highly specific).. 2. Diversity : . ( each antigen there is specific T-cell and B-cell for it).. There are lots of . micoorganisms. that we . encounter everyday . through breathing, touching, and eating. . Most are detected and . destroyed within minutes or hours . by defense mechanisms that do not rely on the clonal expansion of antigen-specific lymhphocytes. .