PPT-GenABEL : an R package for Genome Wide Association Analysis

Younghun Han Department of Epidemiology UT MD Anderson Cancer Center Outline Introduction GeneABEL GWAAdata class Importing data to GenABEL Genetic data QC GWA association analysis. Andrew Morris. Advanced Topics in GWAS. Toronto, 30 May 2012. Introduction. GWAS have been successful in detecting . novel loci for complex traits:. typically characterised by common variants of modest effect;. Presented by Karen . Xu. What you need to know. Basic genetic concepts behind GWAS. Genotyping technologies and common study designs . Statistical concepts for GWAS analysis. Replication, interpretation and follow-up of association results. Lecture 1: Introduction. Linkage studies. Traditional approach to identifying genes for human traits and diseases was through linkage.. For . Mendelian. diseases (e.g. Huntington’s disease) there is a clear co-segregation of genetic markers with disease within pedigrees.. BIOST 2055. 04/01/2015. Human Genome and Single Nucleotide Polymorphisms (SNPs). 23 chromosome pairs. 3 billion bases. A single nucleotide change between pairs of chromosomes. E.g. . Haplotype1. : AAGG. Nadia Khan, Rick Smith, . and Anna . Kuperman. Epigenetics 2012. Introduction. Most Genome Wide Approaches were adapted from technologies originally developed for detecting methylation at the level of a single gene. metritis. in U.S. Holstein cattle . (Paper 610). J.B. Cole,*. 1. K.L. Parker Gaddis,. 2. D.J. Null,. 1. C. Maltecca,. 3. and J.S. Clay. 4. 1. Animal Genomics and Improvement Laboratory, ARS, USDA, Beltsville, MD, USA. Nelson Freimer. UCLA Center for Neurobehavioral Genetics . What makes a genetic association significant?. Outline. The problem of achieving validated findings in psychiatric genetics. Approaches to genetic mapping and statistical significance. Alex Rodriguez * Dinanath Sulakhe Elizabeth Marland arodri7@mcs.anl.gov sulakhe@mcs.anl.gov marland@mcs.anl. Veronika Nefedova Gong Xin Yu Natalia Maltsev * nefedova@mcs.anl.gov gxyu@mcs.anl.g Bas E. Dutilh. March 4. th. 2013. Protein function. Phenotypic. . function. E.g. . apoptosis. GO: . Biological. . process. Cellular. . function. E.g. . ribosome. GO: . Cellular. component. Molecular. Genomics Lesson 12_1. Ross . Hardison. 4/19/15. 1. Genetic association. The occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.. Kesheng Wang, PhD. Department of Biostatistics and Epidemiology. College of Public Health. East Tennessee State University. 2. Outline. Introduction . Alcohol dependence (AD). Genetic study. . Subjects and Methods. T.H. Beaty. FaceBase. Meeting. June 5, 2010. Pittsburgh PA. A bit of background. Both cleft lip with/without cleft palate (CL/P) & cleft palate (CP) show strong familial aggregation. Twin & family studies show clear evidence of genetic control. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Outline. General . overview of association . studies. Sample Results. Three steps to GWAS:. Primary scan. Replication. Fine mapping. Individual Site Score. emm1. invasive Group A . Streptococcus. isolated from Belgian patients during 1994˗2013 . J. Coppens. 1. , . B. B. . Xavier,. . J. Sabirova. 1. , C. Lammens. 1. , K. Loens. 2. , S. Malhotra-Kumar.