PPT-Inflammation-5

Manar Hajeer MD FRCPath Plasma derived mediators of acute inflammation Complement system Coagulation and Kinin systems Complement system Complement components are C1 C9 circulate in the blood in an inactive form. What is inflammation?. it’s a body response against ( MILD or MODERATE) injury , it’s a first line of defense. .. Not severe enough to cause cell death (necrosis).. . Inflammation is of two types:. . classification of acute inflammation. :. according to the inflammatory fluid exudates, . -Exudates . are any fluid that filters from the circulatory system into lesions or areas of inflammation. 1- . Joseph Burdon + Tim . Sargeant. Inflammation. = . a localized physical condition in which part of the body becomes . reddened, swollen, hot, . and often . painful. , especially as a reaction to injury or infection.. Its purpose is to . localize. ,. . eliminate. the injurious . agent, . remove . damaged tissue . and . replace. it with healthy new tissue (. repair. ). . It consist principally of vascular changes associated with leukocyte infiltration and systemic reaction.. . Redha. AL-. Sabbagh. . definition . Acute. . inflammation. is a rapid host response that serves to deliver leukocytes and plasma proteins, such as antibodies, to sites of infection or tissue injury. J. Matthew Velkey. matt.velkey@duke.edu. 454A Davison, Duke South (green zone). Cellular Adaptation to Injury or Stress. Injury or Stress. Increased demand. Decreased stimulation or lack of nutrients. LEC.1. General Features . Inflammation is defined as "the response of living . vascularized. tissues to harmful agents.”. . It consists principally of vascular changes associated with leukocytes infiltration and systemic reactions. , MD. .. Department of Pathology. Faculty of Medicine, . Naresuan. University. Learning Objectives . อธิบายความหมายของการอักเสบชนิดต่างๆ ได้. Prof.Dr. . . Baydaa. . H. . Abdullah. Inflammation. Is a protective response. The body’s response to injury. Interwoven with the repair process. Inflammation. Types. Acute (sec, mins, hrs). Chronic (days, weeks, months, yrs). Prof.Dr. . . Baydaa. . H.Abdullah. Chronic Inflammation. :. An immune reaction to some mild but persistent antigen producing proliferation of Lymphocytes and/or plasma cells. .. There are usually no pain, redness, swelling, or warmth. Faculty of Medicine. Al-Balqa’ Applied University. Email: ali.alkhader@bau.edu.jo. Overview. A protective response . …involving . host cells, blood vessels, and . molecules. . …for the elimination of:. DR. AYSER HAMEED. The major local manifestations of acute inflammation, compared to normal . . Vascular . dilation and increased blood flow (causing erythema and warmth). . . E. xtravasation . and deposition of plasma fluid and proteins (edema), and . By Ajay Kumar What is inflammation? A normal response of living tissues to injury. It prepares the tissue for healing and repair. Ultimate goal is to replace injured tissue. EFFECT OF INFLAMMATION: Th Liver Liver Inflammation, [Acute, Suppurative, Chronic, Chronic active, Granulomatous Figure Legend:Figure 1 Focal inflammation in a female B6C3F1 mouse from a subchronic study. Figure 2 Focal inflamm