PPT-Hemolytic Anemia: Immune Anemias

19 Learning ObjectivesLevel I At the end of this unit of study the student should be able to List the antibody systems or specificities usually involved in cold agglutinin syndrome paroxysmal cold hemoglobinuria PCH. Ellis J. Neufeld MD, PhD. Disclosure Information. Ellis J. Neufeld MD, PhD. Research Funding: . Agios. Pharmaceuticals. Advisory Board: . Agios. Pharmaceuticals. Hemolytic Anemia. Increased . destruction . Anemia:. Deficiency of hemoglobin in the blood.. Causes: . Too few RBCs.. Too little hemoglobin in cells. Decreased packed cell volume.. This may be due to. :. decreased production of RBCs.. increased destruction.. RBCs destroyed. prematurely.. Arrows. . indicate cells. being destroyed; . Acquired (. thru . ertain. chemicals. or bacteria/viruses) . o. r . inherited.. Symptom of o. ther disorders.. Sofi. MD; FRCP (London); . FRCEdin. ; . FRCSEdin. Hemolytic anemia. is a form of anemia due to . hemolysis. , the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular) or elsewhere in the human body (. An interesting phenomenon of rare numbers. .. Meghan E. Kapp, MD MS. 30 June 2014. Hemolytic Anemia. Red Blood Cells are destroyed and removed from the bloodstream before their normal lifespan is over. Ali Al Khader, M.D.. Faculty of Medicine. Al-Balqa’ Applied University. Email: ali.alkhader@bau.edu.jo. Sickle Cell Anemia. The . most common familial hemolytic . anemia in . the . world. Sickle . cell . Michael R. Jeng, MD. Michael R. Jeng, MD. NO FINANCIAL DISCLOSURES. 1. Red blood cell biology. 2. Hemolytic anemia: definition, assessment. 3. Approach to diagnosis. 4. . Microangiopathic. hemolytic anemias. What is anemia. What are symptoms and signs of anemia. What is classification and different types of anemia. What are causes of different types of anemia. Learning Objectives. Anaemia. Significant reduction . Khazaal. Jumaa. F.I.B.M.S (Internal Medicine). F.I.B.M.S (Clinical Hematology). Objectives:. Definition of Hemolytic anemia. Classification. Clinical presentation. Approach consideration. Immune – mediated hemolytic anemia. HEMOLYTIC ANEMIA Summary • MyriadcausesofincreasedRBC • Myriad causes of increased RBC destruction • Marrowfunctionusuallynormal • Marrow function usually normal •Often requi How to classify . anemias. on the basis. of etiology and RBC parameters:. 1.) Decreased production vs. RBC loss (increased destruction or bleeding). 2.) RBC Size:. Macrocytic . ,. microcytic , normocytic. 19/02/2015. Khalid Al-. Anazi. Cytopenias. ** . Low WBC counts:. . - . Neutropenia - . Lymphocytopenia. - . Monocytopenia. ** . Low . Hb. level:. . - Normocytic Anemia - Microcytic Anemia - Macrocytic Anemia. S. Al-. Qahtani. ASSOCIATE PROFESSOR. CONSULTANT . HAEMATOLOGIST . DEPARTMENT OF PATHOLOGY. LEARNING OBJECTIVES. To be able to define haemolysis and hemolytic anemia.. To be able to classify hemolytic anemias into congenital and acquired types, and to know the etiological factors in each division.. DR AMRITA KURIAN. JUNIOR RESIDENT. INTRODUCTION . Hemolytic anemia – classification : . Inherited / Acquired. Acute / Chronic. Intravascular / Extravascular. Intracorpuscular. / . Extracorpuscular.