11bHSD1 Why this pesky enzyme is widening your waistline By Carrie Jones ND MPH Disclosures Medical Director of Precision Analytical Inc Copyright 2017 Carrie Jones ND MPH Copyright 2017 Carrie Jones ND MPH ID: 771028
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11bHSD1: Why this pesky enzyme is widening your waistline! By: Carrie Jones, ND, MPH
Disclosures: Medical Director of Precision Analytical, Inc. Copyright 2017: Carrie Jones, ND, MPH
Copyright 2017: Carrie Jones, ND, MPH
What is the (simplified) stress response? Copyright 2017: Carrie Jones, ND, MPH
Copyright 2017: Carrie Jones, ND, MPH 11-Beta hydroxysteroid dehydrogenase
Where is 11bHSD1 most prevalent? Copyright 2017: Carrie Jones, ND, MPH
Where is 11bHSD2 most prevalent? Copyright 2017: Carrie Jones, ND, MPH
It’s a balance, right? Copyright 2017: Carrie Jones, ND, MPH
This is a fat cell Copyright 2017: Carrie Jones, ND, MPH
In the fat cell… Cortisone Cortisol 11bHSD1 Copyright 2017: Carrie Jones, ND, MPH Even when cortisol everywhere else in the body is ‘in balance’ it can get amplified in fat cells
The Result? Copyright 2017: Carrie Jones, ND, MPH
How do I test 11bHSD activity? Research says you have to look at urinary cortisol and cortisone metabolites THF (cortisol) to THE (cortisone) ratio Copyright 2017: Carrie Jones, ND, MPH
Testing: ↑ Total cortisol production/metabolism Prefers cortisol systemically due to 11bHSD1 Copyright 2017: Carrie Jones, ND, MPH
Increases 11bHSD1 Genetics Inflammation Insulin Obesity itself Thyroid dysfunction Licorice supplementation Glucocorticoid use Copyright 2017: Carrie Jones, ND, MPH
Treatment goals! Copyright 2017: Carrie Jones, ND, MPH
Consider: Address the inflammation, thyroid, insulin, hormones, licorice supplementation or medication Flavonoids Magnolia EGCG Zizyphus vulgaris Scutellaria baicalensis Ocinum sanctumHealthy bile acidCopyright 2017: Carrie Jones, ND, MPH
Thank you for listening! Copyright 2017: Carrie Jones, ND, MPH