Poor sanitation Houses lack basic facilities Lack of clean water Crowded living conditions Inadequate sewage system What is cholera and how do the symptoms arise Cholera Cholera bacteria are ingested by humans through faecal contaminated food or water ID: 910665
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Slide1
How the cholera bacterium causes disease
Poor sanitation
Houses lack basic facilities
Lack of clean water
Crowded living conditions
Inadequate sewage system
What is cholera and how do the symptoms arise?
Slide2Cholera
Cholera bacteria are ingested by humans through faecal contaminated food or water.
What is cholera and how do the symptoms arise?
Slide3Cholera
Cholera bacteria penetrate mucus lining of the small intestine using their flagella.
What is cholera and how do the symptoms arise?
Slide4Cholera
Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.
What is cholera and how do the symptoms arise?
Slide5Cholera
Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.
What is cholera and how do the symptoms arise?
Slide6Cholera
Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.
What is cholera and how do the symptoms arise?
Slide7Cholera
Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.
What is cholera and how do the symptoms arise?
Slide8Cholera
The toxin starts a chain of events in the cell which result in chloride channels in the membrane opening.
What is cholera and how do the symptoms arise?
Slide9Cholera
The flood of chloride ions out of the cells into the lumen of the small intestine lowers the water potential.
What is cholera and how do the symptoms arise?
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Slide10Cholera
What happens to the water potential in the small intestinal lumen?
What is cholera and how do the symptoms arise?
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Slide11Cholera
Water floods out of cells into the small intestine by osmosis.
What is cholera and how do the symptoms arise?
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Slide12Cholera
The increased water causes profuse watery diarrhoea. There is so much diarrhoea that the stools eventually turn into a ‘rice water’ colour.
What is cholera and how do the symptoms arise?
Slide13How does the bacterium cause disease?
Lumen of small intestine
Toxin
Chloride Channel
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Water
What is cholera and how do the symptoms arise?